{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:50:45Z","timestamp":1791809445170,"version":"4.3.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:00:00Z","timestamp":1782518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61633018"],"award-info":[{"award-number":["61633018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subjective cognitive decline (SCD) is a common early complaint in mild cognitive impairment (MCI). Evidence for the 21-item SCD-Questionnaire (SCD-Q21) to discriminate MCI from normal controls (NCs) is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the discrimination performance of Chinese SCD-Q21 and compare it with SCD-Q9 for community-based MCI early detection, assess the added value of simple covariates, and determine an optimal SCD-Q21 cut-off.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>294 NCs and 83 people with MCI were assessed and collected demographic and clinical data. Participants completed SCD-Q21, SCD-Q9, Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) scale; clinical adjudication used Montreal Cognitive Assessment-Basic, Clinical Dementia Rating, and Activities of Daily Living. Group comparison, logistic regression and ROC analyses were applied. Optimal cut-offs were derived using the Youden index and AUCs were compared using DeLong tests. Within-MCI analyses contrasted screen-positive versus screen-negative subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total SCD-Q21 scores were higher in MCI, although five items [question 1 (Q1), Q2, Q3, Q11, and Q17] did not differ between groups. In multivariable binary logistic regression models, lower education (OR = 0.786), higher body mass index (BMI) (OR = 17.874), and higher SCD-Q21 total scores (OR = 1.114) were independently associated with MCI, whereas SCD-Q9 was not. Standalone AUCs were 0.662 (SCD-Q21) and 0.640 (SCD-Q9). Combing age, sex, education, BMI, and HAMA\/HAMD with SCD instrument yielded AUC \u223c0.91. SCD-Q21\u2009\u2265\u20097 gave 69.88% sensitivity and 62.93% specificity. Screen-negative MCI cases showed lower vascular\/metabolic comorbidity and lower HAMA\/HAMD scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SCD-Q21 provides independent information but modest stand-alone discrimination. As part of a brief multivariable triage including education, BMI, vascular risk review, and anxiety rating, it supports efficient case-finding in community settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261463667","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T11:10:21Z","timestamp":1782558621000},"page":"1887-1894","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An application study: 21-item Subjective Cognitive Decline Questionnaire in detecting mild cognitive impairment"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4869-4251","authenticated-orcid":false,"given":"Lixiao","family":"Hao","sequence":"first","affiliation":[{"name":"Xuanwu Hospital of Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xing","sequence":"additional","affiliation":[{"name":"University of Nottingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0377-7424","authenticated-orcid":false,"given":"Ying","family":"Han","sequence":"additional","affiliation":[{"name":"Xuanwu Hospital of Capital Medical University"},{"name":"Xuanwu Hospital of Capital Medical University"},{"name":"Xuanwu Hospital of Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,27]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.939"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102497"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.06.019"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000055"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2019.01.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2015.09.004"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2021.1980860"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2709"},{"key":"e_1_3_3_11_2","first-page":"2349","article-title":"Chinesization of the 21-item Subjective Cognitive Decline Questionnaire","volume":"24","author":"Hao LX","year":"2021","unstructured":"Hao LX, Xing Y, Jia JG, et al. 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