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AD is associated with altered humoral immunity, which may play a role in its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate alterations in plasma levels of B lymphocyte-associated cytokines and their clinical relevance in AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed quantitative detections of 13 cytokines associated with B lymphocytes (TNF-\u03b2, IL-13, IFN-\u03b3, TNF-\u03b1, IL-2, BAFF, IL-6, CD40L, IL-10, IL-12p70, IL-4, IL-17A, and IL-7) in plasma and analyzed their associations with cognitive functions and biomarkers of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that plasma levels of CD40L, BAFF, TNF-\u03b2, IL-6 and IL-17A were increased in AD patients. However, the plasma IL-10 concentrations were decreased in A\u03b2-PET\n                      <jats:sup>+<\/jats:sup>\n                      subjects. Plasma levels of CD40L, BAFF, TNF-\u03b2, IL-6, IL-17A were negatively associated with the plasma A\u03b2\n                      <jats:sub>42\/40<\/jats:sub>\n                      ratio. Plasma levels of IL-10 were negatively associated with pTau181. Plasma levels of BAFF were negatively associated with MMSE scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings demonstrate an altered B lymphocyte-associated cytokine secretion profile in AD patients, which correlates with the clinical severity and biomarkers of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261464184","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:26:13Z","timestamp":1783430773000},"page":"1920-1930","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma profiling of B lymphocyte-associated cytokines in Alzheimer's disease"],"prefix":"10.1177","volume":"112","author":[{"given":"Meng-Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of 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