{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:34:36Z","timestamp":1792787676525,"version":"4.5.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Oiandongnan zhou kehe pingtai","award":["NO.0002-1"],"award-info":[{"award-number":["NO.0002-1"]}]},{"name":"the Science and Technology Fund Project of the Guizhou Provincial Health Commission","award":["gzwkj2024-109"],"award-info":[{"award-number":["gzwkj2024-109"]}],"id":[{"id":"https:\/\/ror.org\/027yzwq33","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The associations between agitation, cerebrospinal fluid (CSF) biomarkers, and cognitive decline, and whether these relationships vary by\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotype, remain unclear in Alzheimer's disease (AD) and mild cognitive impairment (MCI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To investigate the association between CSF biomarkers and agitation in cognitively impaired individuals, with a focus on the potential moderating role of\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 491 cognitively impaired individuals (359 MCI and 132 AD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with available CSF biomarker data. Neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory (NPI), focusing on agitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers, agitation was significantly associated with higher CSF GAP-43 (OR\u2009=\u20091.584, 95% CI: 1.159\u20132.195, p\u2009=\u20090.005) and p-tau levels (OR\u2009=\u20091.49, 95% CI: 1.073\u20132.101, p\u2009=\u20090.02). These associations were not observed in non-carriers. In addition,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers with agitation showed a higher risk of progression to dementia compared with other groups (HR\u2009=\u20094.422, 95% CI: 2.542\u20137.692, p\u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      CSF GAP-43 and p-tau levels are associated with agitation in\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 carriers. Agitation in this subgroup is also associated with an increased risk of progression to dementia, suggesting that it may reflect underlying disease-related processes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261464188","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:35:32Z","timestamp":1782844532000},"page":"1970-1980","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>APOE<\/i>\n                    \u03b54-specific associations between agitation, cerebrospinal fluid biomarkers, and cognitive decline in cognitively impaired patients"],"prefix":"10.1177","volume":"112","author":[{"given":"Xiaochen","family":"Du","sequence":"first","affiliation":[{"name":"China-Japan Friendship Hospital (Institute of Clinical Medical Sciences)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Wang","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Zhao","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital (Institute of Clinical Medical Sciences)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Liu","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital (Institute of Clinical Medical Sciences)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8038-3192","authenticated-orcid":false,"given":"Dantao","family":"Peng","sequence":"additional","affiliation":[{"name":"China-Japan Friendship Hospital (Institute of Clinical Medical Sciences)"},{"name":"China-Japan Friendship Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2014.13060821"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2014.02.007"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13081195"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2014.924900"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2023.2291966"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000363500"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12557"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.01.012"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.11.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-4-48"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410300410"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjment-2025-301752"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.12.019"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0041-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12890"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201417"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44374-w"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.08.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31873-5"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.03.003"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30412-9"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70329"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181cb3e25"},{"key":"e_1_3_3_26_2","article-title":"Effect of SSRIs on clinical progression in amnestic mild cognitive impairment stratified by Alzheimer\u2019s disease pathology","volume":"21","author":"Li Y","year":"2025","unstructured":"Li Y, Liu W, Wang X, et al. 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