{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:12:16Z","timestamp":1789463536014,"version":"build-2803163510"},"reference-count":6,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent anti-amyloid trials have been interpreted as evidence of clinical benefit in Alzheimer's disease, although their relevance remains debated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To reinterpret pooled randomized evidence on anti-amyloid therapies within a Bayesian framework focused on benefit and harm.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pooled estimates from a recent Cochrane review were reanalyzed using posterior probability estimation with clinically relevant thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The probability that treatment effects reached clinically meaningful thresholds was generally low, whereas the probability of substantial harm, particularly amyloid-related imaging abnormalities, was high.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Current randomized evidence suggests that statistically significant anti-amyloid effects may not translate into clinically meaningful benefit.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261469870","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T13:39:56Z","timestamp":1784813996000},"page":"593-597","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Do anti-amyloid therapies demonstrate clinically meaningful benefit? A Bayesian reappraisal"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0822-862X","authenticated-orcid":false,"given":"Tommaso","family":"Costa","sequence":"first","affiliation":[{"name":"Functional Neuroimaging and Complex Neural Systems (FOCUS) Laboratory, Department of Psychology, University of Turin, Turin, Italy"},{"name":"Computational Neuroimaging &amp; Complex Systems Group, GCS-fMRI, Koelliker Hospital, Turin, Italy"},{"name":"Neuroscience Institute of Turin (NIT), Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano L.","family":"Sensi","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging, and Clinical Sciences (DNISC), G. d'Annunzio University of Chieti-Pescara, Chieti, Italy"},{"name":"Center for Advanced Studies and Technology (CAST), G. d'Annunzio University of Chieti-Pescara, Chieti, Italy"},{"name":"Institute for Advanced Biomedical Technologies (ITAB), G. d'Annunzio University of Chieti-Pescara, Chieti, Italy"},{"name":"Neurology Institute, SS Annunziata University Hospital, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7420-2367","authenticated-orcid":false,"given":"Poul F.","family":"H\u00f8ilund-Carlsen","sequence":"additional","affiliation":[{"name":"Odense University Hospital"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos K.","family":"Robakis","sequence":"additional","affiliation":[{"name":"Medicine at Mount Sinai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryce","family":"Vissel","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Centre"},{"name":"School of Clinical Medicine, UNSW Medicine &amp; Health, St Vincent's Healthcare Clinical Campus, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto J.","family":"Espay","sequence":"additional","affiliation":[{"name":"University of Cincinnati"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,23]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1566067"},{"key":"e_1_3_3_3_2","article-title":"Amyloid-\u03b2\u2013targeting monoclonal antibodies for mild cognitive impairment or mild dementia due to Alzheimer\u2019s disease","volume":"4","author":"Nonino F","year":"2026","unstructured":"Nonino F, Minozzi S, Sambati L, et al. Amyloid-\u03b2\u2013targeting monoclonal antibodies for mild cognitive impairment or mild dementia due to Alzheimer\u2019s disease. 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