{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:12:05Z","timestamp":1789463525916,"version":"build-2803163510"},"reference-count":16,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K10653"],"award-info":[{"award-number":["JP24K10653"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25K19014"],"award-info":[{"award-number":["JP25K19014"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24dk0207068"],"award-info":[{"award-number":["JP24dk0207068"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP25dk0207075"],"award-info":[{"award-number":["JP25dk0207075"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:p>Lecanemab is dosed by body weight but supplied as fixed-size single-dose vials, which can leave unavoidable leftover drug after preparation. Using published summary statistics from the Japanese lecanemab post-marketing surveillance on body weight, we fitted a body-weight distribution and ran Monte Carlo simulations. Uncertainty was quantified by a parametric bootstrap. With current 200\/500-mg vials, mean waste rate was 8.60%. A strategy with 200\/250-mg vials reduced waste to 6.30%, and adding a 75-mg vial (\u22644 vials\/infusion) to 3.67%. At 10,000 person-years, annual waste cost was \u223c\u00a52.36 billion under assumed pricing. Vial-size and dispensing optimization may help reduce avoidable waste.<\/jats:p>","DOI":"10.1177\/13872877261469872","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:22:49Z","timestamp":1784632969000},"page":"598-602","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Projected lecanemab wastage from vial discard: Simulation based on Japanese interim post-marketing surveillance summary statistics"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4351-9526","authenticated-orcid":false,"given":"Kenichiro","family":"Sato","sequence":"first","affiliation":[{"name":"The University of Tokyo Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Niimi","sequence":"additional","affiliation":[{"name":"The University of Tokyo Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology"},{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7308-5314","authenticated-orcid":false,"given":"Atsushi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology"},{"name":"Tokyo Metropolitan Institute for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwatsubo","sequence":"additional","affiliation":[{"name":"The University of Tokyo Hospital"},{"name":"National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2024.5292"},{"key":"e_1_3_3_5_2","unstructured":"National Academies of Sciences Engineering and Medicine. Medications in Single-Dose Vials: Implications of Discarded Drugs.https:\/\/www.nationalacademies.org\/read\/25911 (2021)."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.5890"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2026.100541"},{"key":"e_1_3_3_8_2","unstructured":"CMS. Discarded Drugs. https:\/\/www.cms.gov\/medicare\/payment\/part-b-drugs\/discarded-drugs (accessed February 6 2026)."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.17891"},{"key":"e_1_3_3_10_2","article-title":"Overspending driven by oversized single dose vials of cancer drugs","volume":"352","author":"Bach PB","year":"2016","unstructured":"Bach PB, Conti RM, Muller RJ, et al. Overspending driven by oversized single dose vials of cancer drugs. Br Med J 2016; 352: i788.","journal-title":"Br Med J"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2018.06.004"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6963-14-57"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-020-05822-1"},{"key":"e_1_3_3_14_2","unstructured":"United States Pharmacopeia (USP). General Chapter 797 Pharmaceutical Compounding\u2014Sterile Preparations. https:\/\/www.usp.org\/compounding\/general-chapter-797 (accessed February 6 2026)."},{"key":"e_1_3_3_15_2","volume-title":"Guidance on the appropriate use of injectable anticancer drugs and handling of residual solution [in Japanese]","author":"Ministry of Health, Labour and Welfare (Japan)","year":"2018","unstructured":"Ministry of Health, Labour and Welfare (Japan). Guidance on the appropriate use of injectable anticancer drugs and handling of residual solution [in Japanese]. Chiyoda-ku, Tokyo, Japan: Ministry of Health, Labour and Welfare, 2018, (Pharmaceuticals and Medical Devices System Subcommittee; Reference Material 2). https:\/\/www.mhlw.go.jp\/file\/05-Shingikai-10601000-Daijinkanboukouseikagakuka-Kouseikagakuka\/0000203050.pdf."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(24)00335-1"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2025.2609499"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261469872","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261469872","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261469872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:11:38Z","timestamp":1789459898000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261469872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1177\/13872877261469872"],"URL":"https:\/\/doi.org\/10.1177\/13872877261469872","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]}}}