{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:10:30Z","timestamp":1789463430190,"version":"build-2803163510"},"reference-count":96,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministery of Science, Technology and Innovation of Colombia","award":["Project 121584468097, grant 844\/2019, contract 416"],"award-info":[{"award-number":["Project 121584468097, grant 844\/2019, contract 416"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"\n Background<\/jats:title>\n Differential expression of long non-coding RNAs (lncRNAs) in brain, serum, and blood show strong potential to distinguish Alzheimer's disease (AD) from healthy controls.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To explore whether lncRNA signatures delineate AD pathology and map to distinct, multidimensional cognitive domains, enhancing specificity in assessing AD severity and progression.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We profiled 29,603 lncRNAs transcripts in blood samples from 15 AD patients and 15 healthy controls, alongside comprehensive neuropsychological assessments. Generalized Linear Models and Predictive Power Score analyses, with statistical prioritization, identified lncRNAs associated to AD neuropsychological architecture.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Several lncRNAs share strongly associated with cognitive performance and AD severity, mapping to genes involved in key AD-related molecular processes, including synaptic and neurotransmitter regulation (e.g.,\n EPHB1<\/jats:italic>\n ,\n CHRNA4<\/jats:italic>\n ,\n TEAD1<\/jats:italic>\n ), protein homeostasis and A\u03b2 pathology (e.g.,\n FBXL2<\/jats:italic>\n ,\n FAM221A<\/jats:italic>\n ,\n APP<\/jats:italic>\n ), mitochondrial function and cellular stress (e.g.,\n VDAC3<\/jats:italic>\n ,\n PPT2-EGFL8<\/jats:italic>\n ), neuroinflammation and immune regulation (e.g.,\n TEAD1<\/jats:italic>\n ,\n EMX2OS<\/jats:italic>\n ,\n LY6E-DT<\/jats:italic>\n ), epigenetic and transcriptional control (e.g.,\n PRDM2<\/jats:italic>\n ,\n DLEU1<\/jats:italic>\n ,\n FIRRE<\/jats:italic>\n ), neuronal excitability (e.g.,\n KCNJ14<\/jats:italic>\n ), and neuroprotection and synaptic plasticity (e.g.,\n SIL1<\/jats:italic>\n ). Novel associations included ferroptosis, DNA stability, microtubule dynamics, and dendritic orientation (e.g.,\n BTB3<\/jats:italic>\n ,\n DICER1<\/jats:italic>\n ,\n GNG7<\/jats:italic>\n ,\n IBA57<\/jats:italic>\n ,\n NEAT1<\/jats:italic>\n ,\n POT1<\/jats:italic>\n ,\n SRD5A3<\/jats:italic>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We identify candidate lncRNA signatures that may serve as potential biomarkers and enhance our understanding of the molecular basis of the cognitive architecture in AD, opening new avenues for biomarker identification and targeted therapeutic strategies development. Validation in larger, diverse cohorts is essential to confirm their mechanistic contributions to AD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/13872877261470430","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:14:56Z","timestamp":1785330896000},"page":"701-720","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Novel blood lncRNA biomarkers associated with clinical severity and specific cognitive dimensions in Alzheimer's disease"],"prefix":"10.1177","volume":"113","author":[{"given":"Mar\u00eda I.","family":"Mosquera-Heredia","sequence":"first","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar M.","family":"Vidal","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"Instituto Colombiano de Neuropedagog\u00eda, Barranquilla, Colombia"},{"name":"Department of Health Sciences, Universidad de La Costa, Barranquilla, Colombia"},{"name":"Grupo Internacional de Investigaci\u00f3n Neuro-Conductual (GIINCO), Universidad de La Costa, Barranquilla, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C.","family":"Morales","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Silvera-Redondo","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel A.","family":"Bol\u00edvar","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Allegri","sequence":"additional","affiliation":[{"name":"FLENI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Arcos-Burgos","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Psiquiatr\u00eda (GIPSI), Departamento de Psiquiatr\u00eda, Instituto de Investigaciones M\u00e9dicas, Facultad de Medicina, Universidad de Antioquia, Medell\u00edn, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Garavito-Galofre","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3146-7899","authenticated-orcid":false,"given":"Jorge I.","family":"V\u00e9lez","sequence":"additional","affiliation":[{"name":"Universidad del Norte"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14080818"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00696"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2021.02.006"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncrna.2024.03.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2014.03.004"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/EXP.20230154"},{"key":"e_1_3_3_8_2","article-title":"Mini-mental state examination (MMSE) for the detection of Alzheimer\u2019s disease and other dementias in people with mild cognitive impairment (MCI)","volume":"2015","author":"Arevalo-Rodriguez I","year":"2015","unstructured":"Arevalo-Rodriguez I, Smailagic N, Roqu\u00e9i Figuls M, et al. 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