{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:11:00Z","timestamp":1789463460541,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"S&B FOODS INC","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"the BIKEN Foundation","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"Research Unit of Ehime University","award":["None"],"award-info":[{"award-number":["None"]}]},{"name":"JSPS KAKENHI","award":["20K10249, 21H03199, and 24K13263"],"award-info":[{"award-number":["20K10249, 21H03199, and 24K13263"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epidemiological studies have suggested a possible association between tooth loss and dementia, yet evidence regarding mild cognitive impairment (MCI) remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We examined the association between the number of remaining teeth and functional tooth units (FTUs) and the prevalence of MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 8697 adults aged 20\u201395 years (3786 men and 4911 women) were included. Dental status was assessed visually, excluding third molars. MCI was defined as a score of less than 26 on the Japanese version of the Montreal Cognitive Assessment. Participants were categorized into five groups based on the FTUs of natural teeth (n-FTUs) and total FTUs: n-FTUs \u226510; n-FTUs 6\u20139 and total FTUs \u226510; n-FTUs 6\u20139 and total FTUs &lt;10; n-FTUs &lt;6 and total FTUs \u226510; and n-FTUs &lt;6 and total FTUs &lt;10.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of MCI was 35.5%. A reduced number of teeth was significantly associated with the higher prevalence of MCI (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for trend &lt;0.0001). Compared with having n-FTUs \u226510, having n-FTUs &lt;6 and total FTUs \u226510, and having n-FTUs &lt;6 and total FTUs &lt;10 were independently associated with a higher prevalence of MCI. There was no association between having 6\u20139 n-FTUs, regardless of total FTUs, and the prevalence of MCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Even when occlusal function is maintained through prosthodontic restorations, a reduced number of natural teeth is independently associated with MCI, underscoring the importance of preserving natural dentition for maintaining cognitive health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261470790","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:23:42Z","timestamp":1785425022000},"page":"747-755","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between number of teeth and functional tooth units and prevalence of mild cognitive impairment in Japan: Baseline data from the Aidai Cohort Study"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3748-5799","authenticated-orcid":false,"given":"Keiko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health, Ehime University Graduate School of Medicine, Ehime University, Ehime, Japan"},{"name":"Ehime University Food and Health Function Research Center, Ehime, Japan"},{"name":"Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan"},{"name":"Center for Data Science, Ehime University, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Research Team for Social Participation and Community Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, 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Ehime University, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromasa","family":"Kato","sequence":"additional","affiliation":[{"name":"Kato Dental Clinic, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuichi","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Community Medical Support Center, Ehime University Hospital, Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0690-8568","authenticated-orcid":false,"given":"Eizen","family":"Kimura","sequence":"additional","affiliation":[{"name":"Integrated Medical and Agricultural School of Public Health, Ehime University, Ehime, Japan"},{"name":"Center for Data Science, Ehime University, Ehime, Japan"},{"name":"Department of Medical Informatics, Ehime University Graduate School of Medicine, Ehime University, Ehime, 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