{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:10:33Z","timestamp":1789463433059,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG067428"],"award-info":[{"award-number":["R01 AG067428"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG068183"],"award-info":[{"award-number":["R01 AG068183"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG074302"],"award-info":[{"award-number":["R01 AG074302"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hearing impairment (HI) has been identified as a potentially modifiable risk factor for dementia, yet its relationship with Alzheimer's disease (AD) neuropathology and the temporal directionality remain unclear, particularly in late life.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine cross-sectional and longitudinal associations between HI, clinical cognitive status, and AD biomarkers in community-dwelling older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We included 474 DRIVES Project participants (mean age 73.5\u2009\u00b1\u20095.2 years). Hearing was assessed using the NIH Toolbox Words-in-Noise (WIN) test. Clinical cognitive status was assessed using Clinical Dementia Rating (CDR). AD biomarkers included cerebrospinal fluid (CSF) A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      \/A\u03b2\n                      <jats:sub>40<\/jats:sub>\n                      , t-tau\/A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , and p-tau\/A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ratios and amyloid PET imaging. Multivariable linear, logistic, Cox proportional hazards, and Fine\u2013Gray competing-risk models were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HI was more prevalent among participants with mild cognitive impairment (MCI; defined as CDR\u2009=\u20090.5) than cognitively normal individuals (50% versus 24%, p\u2009&lt;\u20090.001), and MCI status was independently associated with worse baseline WIN thresholds (\u03b2\u2009=\u20091.55\u2005dB SNR; 95% CI 0.72\u20132.37). HI was not cross-sectionally associated with CSF amyloid or tau ratios or amyloid PET positivity. Longitudinally, baseline MCI was associated with a higher risk of incident HI (Cox HR\u2009=\u20092.63, 95% CI 1.48\u20134.67; Fine\u2013Gray sHR\u2009=\u20092.79, 95% CI 1.06\u20137.40), whereas baseline HI was not associated with subsequent CDR progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In older adults, HI was associated with MCI but not core AD biomarkers or future CDR progression, suggesting that late-life HI may reflect cognitive vulnerability or broader brain aging rather than independently driving AD pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261470816","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:04:48Z","timestamp":1785247488000},"page":"769-780","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hearing in noise and cognitive status in older adults: Biomarker associations and bidirectional survival analyses"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6514-0502","authenticated-orcid":false,"given":"Semere","family":"Bekena","sequence":"first","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9022-2317","authenticated-orcid":false,"given":"Ramkrishna K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata","family":"Pal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3400-589X","authenticated-orcid":false,"given":"Yiqi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Francois","family":"Trani","sequence":"additional","affiliation":[{"name":"School of Public Health, Washington University in St. Louis, St. Louis, MO, USA"},{"name":"Department of Psychology, University of Johannesburg, Johannesburg, South Africa"},{"name":"National Conservatory of Arts and Crafts, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-4262","authenticated-orcid":false,"given":"Katrina S.","family":"McClannahan","sequence":"additional","affiliation":[{"name":"Washington University in St Louis School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7966-3509","authenticated-orcid":false,"given":"Ganesh M.","family":"Babulal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA"},{"name":"Department of Psychology, University of Johannesburg, Johannesburg, South Africa"},{"name":"Departments of Neurology and Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06375-x"},{"key":"e_1_3_3_3_2","article-title":"2025 Alzheimer\u2019s disease facts and figures","volume":"21","author":"Alzheimer\u2019s Association","year":"2025","unstructured":"Alzheimer\u2019s Association. 2025 Alzheimer\u2019s disease facts and figures. 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