{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:09:40Z","timestamp":1789463380984,"version":"build-2803163510"},"reference-count":48,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["LX22NPO5107"],"award-info":[{"award-number":["LX22NPO5107"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Addenbrooke's Cognitive Examination\u2013Revised (ACE-R) is a widely used multidomain cognitive screening instrument. However, its performance in routine cognitive outpatient clinics with heterogeneous, diagnostically unselected populations remains insufficiently characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the diagnostic accuracy and clinical utility of ACE-R across the spectrum of cognitive impairment in a real-world cognitive outpatient setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included 348 consecutive patients attending a cognitive outpatient clinic. Diagnostic accuracy was assessed using binary and multiclass classification, and longitudinal cognitive trajectories were analysed using multilevel modelling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>ACE-R reliably differentiated dementia from non-dementia and distinguished Alzheimer's disease from mild cognitive impairment. Discrimination between subjective cognitive impairment and normal cognition was limited, consistent with the absence of objective cognitive deficits in subjective cognitive impairment. The instrument demonstrated greater sensitivity for cortical dementias than for subcortical conditions. Longitudinal analyses showed significant cognitive decline in Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ACE-R is a practical and clinically useful screening tool for routine outpatient settings, particularly for dementia detection. However, limited sensitivity in early-stage impairment and restricted ability to differentiate dementia subtypes support its use within a multimodal diagnostic framework rather than as a standalone instrument.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261471428","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:26:23Z","timestamp":1785425183000},"page":"822-834","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Addenbrooke's Cognitive Examination\u2013Revised in a routine cognitive outpatient clinic"],"prefix":"10.1177","volume":"113","author":[{"given":"Jan Sebastian","family":"Novotn\u00fd","sequence":"first","affiliation":[{"name":"Palack\u00fd University Olomouc"},{"name":"Palack\u00fd University Olomouc"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Thatcher","sequence":"additional","affiliation":[{"name":"Gloucestershire Health and Care NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Shatti","sequence":"additional","affiliation":[{"name":"Cobalt Medical Charity, Cheltenham, UK"},{"name":"Gloucestershire Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Mofardin","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, University Medical Centre, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Raku\u0161a","sequence":"additional","affiliation":[{"name":"University Medical Centre, Maribor"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Kolenc","sequence":"additional","affiliation":[{"name":"General Hospital, Novo Mesto"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matija","family":"Zupan","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, University Medical Centre, Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9494-160X","authenticated-orcid":false,"given":"Senta","family":"Frol","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, University Medical Centre, Ljubljana, Slovenia"},{"name":"Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina \u0160urlan","family":"Popovi\u0107","sequence":"additional","affiliation":[{"name":"University Medical Centre, Ljubljana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janja Pretnar","family":"Oblak","sequence":"additional","affiliation":[{"name":"Department of Vascular Neurology, University Medical Centre, Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Bossert","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun","family":"Kuruvilla","sequence":"additional","affiliation":[{"name":"Gloucestershire Health and Care NHS Foundation Trust"},{"name":"School of Health &amp; Social Care, University of Gloucestershire, Cheltenham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Lyburn","sequence":"additional","affiliation":[{"name":"Cobalt Medical Charity, Cheltenham, UK"},{"name":"Gloucestershire Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Trifiro","sequence":"additional","affiliation":[{"name":"Istituti Clinici Scientifici Maugeri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-8755","authenticated-orcid":false,"given":"Gorazd Bernard","family":"Stokin","sequence":"additional","affiliation":[{"name":"Palack\u00fd University Olomouc"},{"name":"Gloucestershire Hospitals NHS Foundation Trust"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"462","article-title":"Subjective cognitive impairment and Alzheimer\u2019s disease: a two year follow up of 51 subjects during two years","volume":"13","author":"Sambuchi N","year":"2015","unstructured":"Sambuchi N, Muraccioli I, Alescio-Lautier B, et al. 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