{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:09:27Z","timestamp":1789463367917,"version":"build-2803163510"},"reference-count":52,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Older adults diagnosed with Alzheimer's disease (AD) often experience diminished muscle strength, highlighting the continued importance of evaluating muscle function in this population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine the relationship between AD and isokinetic lower limb muscle strength in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional observational study was conducted to examine the association between AD and lower limb isokinetic muscle strength in community-dwelling older adults. AD diagnosis was the independent variable; dependent variables included peak torque, average peak torque, and total work. A standardized isokinetic protocol adapted for older adults with cognitive impairment was used to assess knee (flexion\/extension at 60\u00b0\/s and 180\u00b0\/s) and ankle (dorsiflexion\/plantar flexion at 30\u00b0\/s) strength. Crude and adjusted linear regression models evaluated statistical associations, with significance set at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\u2264\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 80 older adults were included, 50% of whom had a diagnosis of AD. The crude model's analysis showed an association between AD and all knee and ankle isokinetic measurements. When the models were adjusted, the association was maintained only for ankle peak torque (\u03b21\u2009=\u2009-16.23;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\n                      <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\n                      \u20090.048) and ankle average peak torque (\u03b21\u2009=\u2009-13.65;\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009\n                      <jats:italic toggle=\"yes\">&lt;<\/jats:italic>\n                      \u20090.049) at 30\u00b0\/s (plantar flexion).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Alzheimer's disease is associated with lower ankle plantar flexors isokinetic muscle strength in community-dwelling older adults. No significant associations between AD and knee (flexors and extensors) and ankle (dorsiflexors) isokinetic muscle strength were found.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261471888","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:15:26Z","timestamp":1785330926000},"page":"895-905","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring the relationship between Alzheimer's disease and lower extremity isokinetic muscle strength in community-dwelling older adults: A cross-sectional observational study"],"prefix":"10.1177","volume":"113","author":[{"given":"Marcos Paulo Braz De","family":"Oliveira","sequence":"first","affiliation":[{"name":"Physical Therapy Department, Federal University of S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia Lanziotti Azevedo","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora, Juiz de Fora"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8264-3565","authenticated-orcid":false,"given":"Nat\u00e1lia Oiring De Castro","family":"Cezar","sequence":"additional","affiliation":[{"name":"Medicine Department, State University of Minas Gerais, Passos, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Rigo","family":"Lima-Truax","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brendon David","family":"Truax","sequence":"additional","affiliation":[{"name":"The University of Alabama at Birmingham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7074-887X","authenticated-orcid":false,"given":"S\u00f3nia","family":"Brito-Costa","sequence":"additional","affiliation":[{"name":"Centre for Research and Innovation in Education (inED), Polytechnic University of Coimbra, Coimbra, Portugal"},{"name":"Polytechnic University of Coimbra, Institute for Applied Research, Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anielle Cristhine De Medeiros","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, Federal University of S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Regina Mendes Da Silva","family":"Serr\u00e3o","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, Federal University of S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Pires De","family":"Andrade","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, Federal University of S\u00e3o Carlos, S\u00e3o Carlos, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glae061"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.14654"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.833087"},{"key":"e_1_3_3_6_2","article-title":"Is ankle plantar flexor strength associated with balance and walking speed in healthy people? 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