{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:09:16Z","timestamp":1789463356148,"version":"build-2803163510"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia, including Alzheimer's disease, represents one of the fastest-growing global health challenges. To coordinate research priorities, the World Health Organization (WHO) introduced the Blueprint for Dementia Research in 2022. This framework outlines six research themes spanning disease mechanisms, diagnosis, treatment development, risk reduction, epidemiology and health economics, and care and support. However, empirical evidence assessing whether global research activity aligns with these priorities remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To analyse global trends in dementia and Alzheimer's disease research and examine how research output is distributed across the thematic priorities defined in the WHO Blueprint for Dementia Research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 206,636 unique peer-reviewed primary care studies published between 2019 and 2024 were retrieved from databases on the EBSCOhost platform. A machine-learning\u2013assisted natural language processing pipeline classified publications into the six WHO research themes. Temporal trends were assessed and differences in thematic distributions before and after publication of the WHO blueprint were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Annual dementia research output increased from 27,248 publications in 2019 to 39,147 in 2024. Research activity was consistently dominated by studies on disease mechanisms and diagnosis. Risk reduction and drug development demonstrated the strongest growth. Research related to dementia care and support, epidemiology and health economics increased more slowly and declined following publication of the WHO blueprint.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Global dementia research continues to expand but remains unevenly distributed across research priorities. While progress in biomedical discovery is substantial, comparatively limited growth in care-related research highlights the need for stronger investment in studies addressing implementation and real-world dementia care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261471922","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:01:45Z","timestamp":1785247305000},"page":"969-980","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Global trends in Alzheimer's and dementia research (2019\u20132024): A machine learning-based bibliometric analysis"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-9710","authenticated-orcid":false,"given":"Anthony","family":"Scerri","sequence":"first","affiliation":[{"name":"University of Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-1704","authenticated-orcid":false,"given":"Kenneth","family":"Scerri","sequence":"additional","affiliation":[{"name":"University of Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3319-5273","authenticated-orcid":false,"given":"Charles","family":"Scerri","sequence":"additional","affiliation":[{"name":"University of Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","author":"GBD Dementia Collaborators","year":"2022","unstructured":"GBD Dementia Collaborators. Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019. Lancet Public Health 2022; 7: e105\u2013e125.","journal-title":"Lancet Public Health"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12901"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101580"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-00942-2"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00274-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32599-1"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5836"},{"key":"e_1_3_3_9_2","volume-title":"A blueprint for dementia research","author":"World Health Organization","year":"2022","unstructured":"World Health Organization. A blueprint for dementia research. Geneva, Switzerland: World Health Organization, 2022.https:\/\/www.who.int\/publications."},{"key":"e_1_3_3_10_2","first-page":"99","article-title":"Bibliometric analysis of global Alzheimer\u2019s disease research trends","volume":"15","author":"Dong Y","year":"2019","unstructured":"Dong Y, Peng CYJ. Bibliometric analysis of global Alzheimer\u2019s disease research trends. Alzheimers Dement 2019; 15: 99\u2013109.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170184"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40200-025-01812-4"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.5606\/fng.btd.2022.91"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01296-0"},{"key":"e_1_3_3_15_2","volume-title":"Global action plan on the public health response to dementia 2017\u20132025","author":"World Health Organization","year":"2017","unstructured":"World Health Organization. Global action plan on the public health response to dementia 2017\u20132025. Geneva, Switzerland: World Health Organization, 2017.https:\/\/www.who.int\/publications\/i\/item\/global-action-plan-on-the-public-health-response-to-dementia-2017\u20142025."},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-049086"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0277470"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/08919887241232647"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12622"},{"key":"e_1_3_3_20_2","volume-title":"Global Dementia Action Plan extension to 2031","author":"Alzheimer\u2019s Disease International","year":"2024","unstructured":"Alzheimer\u2019s Disease International. Global Dementia Action Plan extension to 2031. 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