{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:57:56Z","timestamp":1790675876251,"version":"4.1.0"},"reference-count":32,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vascular risk factors contribute substantially to late-life cognitive impairment and interact with neurodegenerative processes underlying dementia. Blood\u2013brain barrier (BBB) dysfunction has emerged as a key mechanism linking vascular pathology to cognitive decline; however, circulating biomarkers reflecting BBB remodeling remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To explore the association between circulating markers of BBB remodeling, amyloid-\u03b2 (A\u03b2)\n                      <jats:sub>1\u201340<\/jats:sub>\n                      and longitudinal cognitive decline in individuals with vascular risk factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective cohort study, 101 individuals (mean age 71\u2009\u00b1\u20095 years; 59.4% women) with long-standing hypertension and\/or type 2 diabetes mellitus underwent serial assessment of serum BBB-related biomarkers (matrix metalloproteinases [MMPs], TIMP-1 and soluble tumor necrosis factor-like weak inducer of apoptosis [sTWEAK]), A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      , brain MRI, and standardized cognitive testing (Mini-Mental State Examination and Addenbrooke's Cognitive Examination Version V) over a mean follow-up of 24\u2009\u00b1\u20094.9 months. Cognitive decline was defined as a clinically meaningful reduction in global cognitive scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve participants (11.9%) developed cognitive decline. Higher serum MMP-7 levels at 12 months were independently associated with subsequent cognitive decline after adjustment for age, sex and baseline cognition (adjusted OR 2.13; 95% CI 1.09\u20134.13; p\u2009=\u20090.026). Baseline levels of A\u03b2\n                      <jats:sub>1\u201340<\/jats:sub>\n                      , MMP-9, and sTWEAK were associated with lower cognitive performance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Elevated circulating MMP-7 at 12 months was associated with cognitive decline suggesting a potential role for BBB remodeling in vascular contributions to cognitive impairment. These findings should be considered exploratory and require validation in larger studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261474103","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:25:16Z","timestamp":1785864316000},"page":"1065-1074","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating MMP-7 is associated with cognitive decline in individuals with vascular risk factors"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9295","authenticated-orcid":false,"given":"Iria","family":"L\u00f3pez-Dequidt","sequence":"first","affiliation":[{"name":"Neurology Department, University Clinical Hospital of A Coru\u00f1a, Biomedical Research Institute of A Coru\u00f1a (INIBIC), A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yago","family":"Leira","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry, University of Santiago de Compostela, Santiago de Compostela, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Cinza-Sanjurjo","sequence":"additional","affiliation":[{"name":"Centro de Salud Milladoiro, A Coru\u00f1a, Spain"},{"name":"Health Research Institute of Santiago de Compostela, Santiago de Compostela, A Coru\u00f1a, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rey-Aldana","sequence":"additional","affiliation":[{"name":"Centro de Salud A Estrada, Pontevedra, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela, Santiago de Compostela, A Coru\u00f1a, Spain"},{"name":"Hospital of Santiago de Compostela"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Campos","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom\u00e1s","family":"Sobrino","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS)"},{"name":"Centro de investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Castillo","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela (IDIS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Rodr\u00edguez-Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Health Research Institute of Santiago de Compostela, Santiago de Compostela, A Coru\u00f1a, Spain"},{"name":"Hospital of Santiago de Compostela"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.024148"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30079-1"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12221"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00463-8"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70124-8"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.20630"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.10"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70060-7"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160604"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0006-15.2015"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.188"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864241243274"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-024-02696-z"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"e_1_3_3_18_2","article-title":"Diagnosis and classification of diabetes mellitus","volume":"40","author":"American Diabetes Association","year":"2017","unstructured":"American Diabetes Association. 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