{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:10Z","timestamp":1792787770517,"version":"4.5.0"},"reference-count":58,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Research Funding for Longevity Sciences","award":["25-4"],"award-info":[{"award-number":["25-4"]}]},{"name":"JSPS KAKENHI","award":["16KT0014"],"award-info":[{"award-number":["16KT0014"]}]},{"name":"JSPS KAKENHI","award":["19H03915"],"award-info":[{"award-number":["19H03915"]}]},{"name":"The Japan Geriatrics Society Grant for Geriatric Nutrition Research","award":["None"],"award-info":[{"award-number":["None"]}],"id":[{"id":"https:\/\/ror.org\/02zzfq177","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although a lower body mass index (BMI) has been identified as a prognostic risk factor among older adults with cognitive impairment, it remains unclear which body composition are associated with prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study investigated the relationship between body composition and mortality in older adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This longitudinal study, using data from a memory clinic in Japan, included patients aged \u226565 years who were clinically diagnosed with MCI or AD. Mortality data (date and cause of death) were obtained using a proxy questionnaire. Body composition (muscle mass, fat-free mass, fat mass, %FM) was measured using bioelectrical impedance analysis, and muscle mass index (MMI), fat-free mass index (FFMI) and fat mass index (FMI) were calculated. Body composition index was divided into tertiles (lowest, middle, and highest). To evaluate associations between body composition and mortality, we conducted survival analyses using Cox proportional hazards model (ref. lowest group).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1575 patients were included in the analysis (mean age, 78.2 years; 63.2% women). The highest FMI and %FM groups had a lower risk of mortality than that in the lowest group (hazard ratio [95% confidence interval]: FMI, 0.55 [0.37\u20130.81]; %FM, 0.49 [0.33\u20130.71]), and this association was significant in women with MCI and AD. No significant associations were observed between MMI, FFMI, and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Lower FM may be a potential risk factor for poor prognosis, emphasizing the need to monitor it from an early stage of cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261476079","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T13:22:22Z","timestamp":1786972942000},"page":"1182-1191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between body composition and mortality in older patients with mild cognitive impairment and Alzheimer's disease: NCGG-STORIES"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4860-6754","authenticated-orcid":false,"given":"Kazuaki","family":"Uchida","sequence":"first","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Sugimoto","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"the University of Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9165-5501","authenticated-orcid":false,"given":"Taiji","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Hamamatsu University School of Medicine"},{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayane","family":"Komatsu","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"},{"name":"Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rei","family":"Ono","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"},{"name":"Department of Public Health, Kobe University Graduate School of Health Sciences, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Onoyama","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tami","family":"Saito","sequence":"additional","affiliation":[{"name":"Research Institute, National Center for Geriatrics and Gerontology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,17]]},"reference":[{"key":"e_1_3_3_2_2","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the global burden of disease study 2019","volume":"7","author":"GBD","year":"2022","unstructured":"GBD. 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