{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:57:32Z","timestamp":1790675852277,"version":"4.1.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Amyloid-negative tau-related neurodegeneration represents a non-Alzheimer biomarker-defined profile; however, its clinical heterogeneity and prognostic relevance remain unclear within Alzheimer's disease-related frameworks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To characterize the clinical spectrum and identify predictors of mortality in patients with this profile.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective cohort study, 1280 patients evaluated at a tertiary neurology center were screened, and 130 with an amyloid-negative cerebrospinal fluid (CSF) pattern [amyloid-\u03b2 (A\u03b2)\n                      <jats:sub>42<\/jats:sub>\n                      normal, phosphorylated tau (pTau), and total tau (tTau) elevated] were included. Survival was assessed using Kaplan\u2013Meier analysis, and predictors of mortality were evaluated using Cox models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cohort (mean age 68.8\u2009\u00b1\u200910.1 years; 45.4% female) showed heterogeneous diagnoses, mainly mild cognitive impairment and frontotemporal dementia (each 30%). Survival differed across diagnostic groups (log-rank p\u2009=\u20090.037), with more favorable outcomes in mild cognitive impairment. Male sex was more frequent among non-survivors (88.9% versus 45.6%, p\u2009&lt;\u20090.001). Higher CSF tTau levels were associated with mortality in the joint Cox model (HR 1.003, 95% CI 1.001\u20131.006, p\u2009=\u20090.006) and faster clinical progression (r\u2009=\u20090.22, p\u2009=\u20090.011). When modeled separately, neither tTau nor pTau was independently associated with mortality; however, both became significant in opposite directions when included jointly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The amyloid-negative A\u2212T\u2009+\u2009N\u2009+\u2009profile represents a clinically heterogeneous subgroup with prognostic relevance. CSF tTau was associated with mortality and faster clinical progression, but the joint-model findings involving tTau and pTau should be interpreted cautiously as hypothesis-generating. Further studies are needed to clarify the prognostic value of tau-related biomarkers in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261476236","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:55:43Z","timestamp":1786557343000},"page":"1220-1231","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic significance of cerebrospinal fluid tau biomarkers in amyloid-negative A\u2212T\u2009+\u2009N\u2009+\u2009neurodegeneration: A retrospective cohort study"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6898-0469","authenticated-orcid":false,"given":"Asl\u0131","family":"Aksoy G\u00fcndo\u011fdu","sequence":"first","affiliation":[{"name":"Tekirda\u011f Nam\u0131k Kemal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bedia","family":"Samanc\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Alayl\u0131o\u011flu","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdi","family":"\u015eahin","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7a\u011fr\u0131","family":"Ulukan","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130brahim Hakan","family":"G\u00fcrvit","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdin\u00e7","family":"Dursun","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u015fmet Ayhan","family":"Hana\u011fas\u0131","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Gezen-Ak","sequence":"additional","affiliation":[{"name":"Istanbul University-Cerrahpasa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u015far","family":"Bilgi\u00e7","sequence":"additional","affiliation":[{"name":"Istanbul University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215587"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(21)00140-9"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.251"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz099"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-025-02943-x"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01220-x"},{"key":"e_1_3_3_10_2","first-page":"262","article-title":"Prognostic value of cerebrospinal fluid biomarkers in mild cognitive impairment due to Alzheimer disease","volume":"38","author":"L\u00f3pez-Cuevas R","year":"2023","unstructured":"L\u00f3pez-Cuevas R, Baquero-Toledo M, Cuevas-Jim\u00e9nez A, et al. 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