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N-Myc downstream-regulated gene 2 (NDRG2) is predominantly localized in astrocytes and is implicated in cognitive function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to explore whether cerebrospinal fluid (CSF) NDRG2 could predict MCI and investigate its underlying mechanisms of cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 650 CSF samples were collected from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database, comprising 157 normal individuals, 366 MCI patients, and 127 Alzheimer's disease (AD) patients. One-way analysis of covariance (ANCOVA) was employed to assess differences in CSF NDRG2 levels among groups. Linear regression was used to analyze the correlation between NDRG2 and amyloid-\u03b2 (A\u03b2), phosphorylated tau (p-tau),\n                      <jats:sup>18<\/jats:sup>\n                      F-fluorodeoxyglucose positron emission tomography (FDG-PET), albumin quotient (Qalb), and growth-associated protein 43 (GAP43). Receiver operating characteristic (ROC) curves were used to examine the diagnostic performance of NDRG2 for MCI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CSF NDRG2 levels were significantly reduced in MCI, most prominently in non-A\u03b2 and non-tau subgroups. NDRG2 discriminated A\u03b2-negative MCI with an area under the curve (AUC) of 0.719, but showed limited discriminatory capacity in A\u03b2+, tau+, and apolipoprotein E \u03b54 (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54) carrier groups. Furthermore, CSF NDRG2 levels were positively correlated with GAP-43, a marker of synaptic plasticity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The present study demonstrates that NDRG2 is a potential biomarker for non-AD derived MCI and suggests its involvement in synaptic plasticity impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261477113","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:01:51Z","timestamp":1786629711000},"page":"1420-1439","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Decreased cerebrospinal fluid NDRG2 is associated with non-Alzheimer's disease derived mild cognitive impairment"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0179-159X","authenticated-orcid":false,"given":"Qing-ning","family":"Zhang","sequence":"first","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-ming","family":"Zhou","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-4190-3758","authenticated-orcid":false,"given":"Lan-ke","family":"Yu","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4036-5537","authenticated-orcid":false,"given":"Xin-yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9704-4394","authenticated-orcid":false,"given":"Jia-lin","family":"Wu","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2078-7084","authenticated-orcid":false,"given":"Si-yuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA"},{"name":"Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1276-9234","authenticated-orcid":false,"given":"Zhao-hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Renmin Hospital of Wuhan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12328"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25245789"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-201043"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3543"},{"key":"e_1_3_3_7_2","article-title":"Worldwide prevalence of mild cognitive impairment among community dwellers aged 50 years and older: a meta-analysis and systematic review of epidemiology studies","volume":"51","author":"Bai W","year":"2022","unstructured":"Bai W, Chen P, Cai H, et al. 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