{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:07Z","timestamp":1792787767590,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"National Institutes of Health\u2013National Institute on Aging","award":["R01 AG053184 & R01 AG067021 & R01 AG058825"],"award-info":[{"award-number":["R01 AG053184 & R01 AG067021 & R01 AG058825"]}],"id":[{"id":"https:\/\/ror.org\/049v75w11","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Assessing instrumental activities of daily living (IADLs) is an integral diagnostic process for cognitive decline due to Alzheimer's disease (AD). While there are questionnaire-based and performance-based IADL measures, there is no clear consensus on the best methodology for a preclinical population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We aimed to compare performance-based and questionnaire-based IADL measures and investigate whether IADL measures differently predict cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred and sixty-one cognitively unimpaired participants (mean age=70.69\u2009\u00b1\u20096.33 years; 62% female) completed performance-based IADL measures (i.e., Harvard Automated Phone Task [APT]; Czaja Functional Assessment Battery [CFAB]), questionnaire-based IADL measures (i.e., Cognitive Function Index [CFI]; The Alzheimer's Disease Cooperative Study Activities of Daily Living-Prevention Instrument [ADCS ADL-PI], also completed by study partners), and cognitive assessments. Separate cross-sectional linear regressions were used to determine (1) whether IADL questionnaires predicted performance-based measures, (2) whether IADL assessments predicted cognition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Greater impairment on participant self-reported questionnaires (CFI and ADCS ADL-PI) were associated with worse performance on the CFAB automated teller machine task (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.36, p\u2009=\u20090.010; R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.44, p\u2009=\u20090.003). Worse performance on the APT primary care physician task and greater impairment on participant self-reported CFI were associated with worse executive functioning (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.13, p\u2009=\u20090.003; R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.06, p\u2009=\u20090.035) and slower processing speed (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.15, p\u2009=\u20090.009; R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.22, p\u2009&lt;\u20090.001). Greater impairment on the participant self-reported CFI was the only assessment associated with worse memory scores (R\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.14, p\u2009=\u20090.005).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among cognitively unimpaired older adults, few questionnaire-based IADL questionnaires were associated with performance-based measures. There was variability within and across IADL assessments\u2019 associations with cognition, suggesting that not all IADL assessments are interchangeable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261478266","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T14:56:41Z","timestamp":1787669801000},"page":"1467-1477","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparing the associations between performance-based, participant-reported, and study partner-reported instrumental activities of daily living tasks and cognition in cognitively unimpaired adults"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5978-3445","authenticated-orcid":false,"given":"Abigail T.","family":"LaCasse","sequence":"first","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Department of Clinical Psychology, William James College, Newton, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8707-1826","authenticated-orcid":false,"given":"Catherine E.","family":"Munro","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Truitt","sequence":"additional","affiliation":[{"name":"Cambridge Health Alliance"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Yu","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia R.","family":"Aibel","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onyinye J.","family":"Udeogu","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca E.","family":"Amariglio","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6318-9213","authenticated-orcid":false,"given":"Dorene M.","family":"Rentz","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9096-2355","authenticated-orcid":false,"given":"Gad A.","family":"Marshall","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5708-4925","authenticated-orcid":false,"given":"Mark A.","family":"Dubbelman","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital"},{"name":"Massachusetts General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acw049"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00706-2"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-220885"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.11.018"},{"key":"e_1_3_3_6_2","first-page":"277","article-title":"Assessment of instrumental activities of daily living in preclinical Alzheimer disease","volume":"42","author":"Keleman AA","year":"2022","unstructured":"Keleman AA, Bollinger RM, Wisch JK, et al. 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