{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:57:12Z","timestamp":1791881832905,"version":"4.3.4"},"reference-count":42,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Growing evidence links cardiovascular health to Alzheimer's disease (AD). While elevated plasma homocysteine (Hcy) is associated with cognitive decline, the relationship between cerebrospinal fluid (CSF) Hcy and the core pathological biomarkers of AD remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      This study aimed to investigate the associations of CSF Hcy and plasma Hcy with CSF amyloid-\u03b2 (A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      ), phosphorylated tau (p-tau), and total tau (t-tau).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 294 non-demented participants (110 cognitively normal, 184 with mild cognitive impairment) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database were analyzed. Multivariate linear regression was used to analyze the relationships between CSF and plasma Hcy levels and CSF A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      , phosphorylated tau (p-tau), and total tau (t-tau). Logistic regression analyses assessed the association between Hcy levels and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      positivity, tau positivity, and neurodegeneration positivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      CSF Hcy levels showed significant positive associations with CSF p-tau and t-tau, as well as tau and neurodegeneration positivity. In contrast, no significant association was found between CSF Hcy and A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      pathology. Notably, plasma Hcy was not associated with any AD-related biomarkers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CSF Hcy, rather than plasma Hcy, was associated with markers of tau pathology and neurodegeneration in non-demented older adults. These findings suggest that CSF Hcy may be more closely associated with tau-related pathological processes during the pre-dementia stages of AD. Further research is needed to explore the mechanisms underlying these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261481063","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:20:29Z","timestamp":1788276029000},"page":"1709-1716","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebrospinal fluid homocysteine, but not plasma homocysteine, is associated with markers of tau pathology and neurodegeneration"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3621-6806","authenticated-orcid":false,"given":"Ji Hyung","family":"Lee","sequence":"first","affiliation":[{"name":"Chungbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun Hui","family":"Won","sequence":"additional","affiliation":[{"name":"Chungnam National University Sejong Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Ick","family":"Lee","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung-Woo","family":"Son","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siekyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gawon","family":"Ju","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seungwon","family":"Chung","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1669-6113","authenticated-orcid":false,"given":"Joon Hyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Chungbuk National University Hospital"},{"name":"Department of Psychiatry, College of Medicine Chungbuk National University, Cheongju, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010231"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2022.112045"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-023-04679-2"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.2303"},{"key":"e_1_3_3_6_2","article-title":"Association and interaction of blood homocysteine and p-tau217 levels with temporal cortical thinning and cognitive impairment in Alzheimer\u2019s disease","volume":"21","author":"Wang Q","year":"2025","unstructured":"Wang Q, Zhong X, Gao P, et al. 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