{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:36:06Z","timestamp":1792787766773,"version":"4.5.0"},"reference-count":46,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EDENIS"},{"name":"Pierre-Fabre"},{"name":"KORIAN","id":[{"id":"https:\/\/ror.org\/02b941k82","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Regional Development Fund","award":["MP0022856"],"award-info":[{"award-number":["MP0022856"]}]},{"name":"French National Research Agency","award":["ANR-23-IAHU-0011"],"award-info":[{"award-number":["ANR-23-IAHU-0011"]}],"id":[{"id":"https:\/\/ror.org\/00rbzpz17","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Alzheimer Prevention in Occitania and Catalonia"},{"name":"Region Occitanie\/Pyr\u00e9n\u00e9es-M\u00e9diterran\u00e9e","award":["1901175"],"award-info":[{"award-number":["1901175"]}],"id":[{"id":"https:\/\/ror.org\/05mzwwx48","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Loneliness is the subjective feeling of social isolation and evidence suggests that it increases the risk for cognitive decline and Alzheimer's disease (AD). However, studies examining the associations between loneliness and AD biomarkers are limited and inconclusive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We sought to investigate the relationships between loneliness and plasma tau phosphorylated at threonine 217 (p-tau217) and plasma neurofilament light chain (NfL): peripheral biomarkers of central AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This is a cross-sectional analysis of the \u2018INStitute for Prevention\u2019 \u2018healthy agIng\u2019 and \u2018medicine REjuvenative\u2019 \u2018Translational\u2019 (INSPIRE-T) baseline data. Participants were dementia-free (Mini-Mental State Exam score \u2265 24) community-dwellers aged \u2265 65 years (n\u2009=\u2009434). Loneliness was assessed using the Patient-Reported Outcomes Measurement Information System (PROMIS\n                      <jats:sup>\u00ae<\/jats:sup>\n                      ) Item Bank v2.0, Short Form 8a questionnaire and plasma p-tau217 and plasma NfL were measured using Lumipulse immunoassays. Multiple linear regression was conducted to evaluate the relationships between loneliness (exposure) and plasma biomarkers (outcomes).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Loneliness was not associated with plasma p-tau217 (\u03b2\u2009=\u20090.00458 [95% CI: \u22120.00328, 0.01243], p\u2009=\u20090.253) or plasma NfL (\u03b2\u2009=\u20090.00138 [95% CI: \u22120.00418, 0.00693], p\u2009=\u20090.626) in multiple linear regression models adjusted for age, sex, education, cognitive performance, depressive score, eyesight, hearing, and apolipoprotein \u03b54 (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54) status (model 2). There was no significant moderating effect of sex, depression, eyesight, hearing or\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 on these associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings suggest that loneliness is not associated with plasma p-tau217 or plasma NfL in dementia-free older adults. Perspective studies are warranted to examine these associations further.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261482077","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:50:26Z","timestamp":1788414626000},"page":"1823-1832","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-sectional associations of loneliness with plasma p-tau217 and neurofilament light chain in dementia-free older adults in the INSPIRE-T baseline cohort"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-0198","authenticated-orcid":false,"given":"Claudie","family":"Hooper","sequence":"first","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology and Cytology, Toulouse University Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Delrieu","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Coley","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Soto","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Vellas","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Guyonnet","sequence":"additional","affiliation":[{"name":"IHU HealthAge, Cit\u00e9 de la sant\u00e9, Place Lange, Toulouse, France"},{"name":"Aging Research Team, Centre for Epidemiology and Research in Population health (CERPOP), University of Toulouse-INSERM, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the IHU HealthAge INSPIRE\/Open Science study group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2020.08.005"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1057\/s41599-025-05304-x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-025-03021-8"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/13607863.2011.628977"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172500011X"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-024-00328-9"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2024.100046"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210330"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.64.2.234"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/gbz139"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.899814"},{"key":"e_1_3_3_13_2","article-title":"Alzheimer\u2019s disease facts and figures. 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