{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T08:57:12Z","timestamp":1791881832939,"version":"4.3.4"},"reference-count":79,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["No. 20252BAC200556"],"award-info":[{"award-number":["No. 20252BAC200556"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Engagement in physical, social, and intellectual activities is associated with cognitive health in later life, but how their long-term combinations relate to mild cognitive impairment (MCI), a key preclinical stage of Alzheimer's disease, remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify multi-activity trajectories and examine their associations with MCI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data were from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative biennial survey collecting demographic, socioeconomic, health, cognitive, and activity-related information. We included 1884 participants aged \u226560 years in 2020. Group-based multi-trajectory modeling identified physical, social, and intellectual activity patterns using the 2011, 2013, 2015, and 2018 waves. Multivariable logistic regression examined associations with MCI in 2020, with subgroup analyses by sex, baseline age, education, and residence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four distinct trajectory groups were identified: Moderate PA\u2013low SI (social and intellectual activity), High PA\u2013low SI, Moderate PA\u2013higher SI, and High PA\u2013moderate SI. The Moderate PA\u2013higher SI group had the lowest MCI prevalence (9.47%) and served as the reference. In the fully adjusted model, MCI odds were highest in the High PA\u2013low SI group (OR\u2009=\u20092.05, 95% CI: 1.34\u20133.15), followed by the Moderate PA\u2013low SI group (OR\u2009=\u20091.57, 95% CI: 1.08\u20132.30). The High PA\u2013moderate SI group was not significantly associated with MCI (OR\u2009=\u20091.38, 95% CI: 0.72\u20132.58).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Moderate physical activity combined with higher social and intellectual engagement was associated with more favorable cognitive outcomes, supporting integrated, pattern-based lifestyle strategies for early prevention of MCI and Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261483186","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:07:25Z","timestamp":1788368845000},"page":"1872-1885","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-trajectories of activity participation and risk of mild cognitive impairment in China: A national longitudinal cohort study"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1424-2019","authenticated-orcid":false,"given":"Ling","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Psychology, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"},{"name":"Key Laboratory of Psychology of TCM and Brain Science, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Psychology, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"},{"name":"Key Laboratory of Psychology of TCM and Brain Science, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Psychology, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"},{"name":"Key Laboratory of Psychology of TCM and Brain Science, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000512597"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.09.003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.13806"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30185-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1720145"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)00150-3"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-025-04092-0"},{"key":"e_1_3_3_9_2","article-title":"The prognosis of mild cognitive impairment: a systematic review and meta-analysis","volume":"17","author":"Salemme S","year":"2025","unstructured":"Salemme S, Lombardo FL, Lacorte E, et al. 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