{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:39:02Z","timestamp":1793090342143,"version":"4.5.0"},"reference-count":61,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dementia is an emerging public health priority in Saudi Arabia, driven by population aging and a high prevalence of vascular and metabolic disease. Despite increasing research activity, evidence remains fragmented, limiting understanding of the national burden and determinants of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To synthesize evidence on dementia epidemiology, risk factors, awareness, comorbidities, caregiving challenges, and research trends in Saudi Arabia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review was conducted following PRISMA 2020 guidelines. PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar were searched for studies reporting dementia-related outcomes in Saudi populations. Given heterogeneity in study designs, sampling methods, and diagnostic criteria, findings were narratively synthesized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty-five studies met the inclusion criteria. Alzheimer's disease was the most common dementia subtype. Prevalence estimates among adults aged 60 years and older ranged from 3.8% to 6.3%, reflecting differences in diagnostic approaches and sampling methods. Diabetes and hypertension were the most consistently identified risk factors, while depression and anxiety were also associated with dementia. Public awareness was low, with stigma contributing to delayed recognition and underdiagnosis. Caregiving was family-based and associated with significant burden. Dementia commonly co-occurs with cardiometabolic, neuropsychiatric, and other chronic conditions. Research activity increased after 2020, with over half of the included studies published between 2020 and 2024; however, methodological inconsistencies and limited rural representation remain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Dementia research in Saudi Arabia has expanded, yet epidemiological estimates remain inconsistent. Standardized diagnostic practices, enhanced surveillance, and public health strategies addressing risk reduction, awareness, and caregiver support are needed to address the dementia burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261485493","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T04:20:17Z","timestamp":1788841217000},"page":"17-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology, risk determinants, and research trends of dementia in Saudi Arabia: A systematic review"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3855-9307","authenticated-orcid":false,"given":"Afm Saiful","family":"Islam","sequence":"first","affiliation":[{"name":"UCL Queen Square Institute of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoha","family":"Saif","sequence":"additional","affiliation":[{"name":"Queen Mary University of London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baraa","family":"Alghalyini","sequence":"additional","affiliation":[{"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Rehman","family":"Zia Zaidi","sequence":"additional","affiliation":[{"name":"Alfaisal University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30235-6"},{"key":"e_1_3_3_3_2","first-page":"141","article-title":"Kingdom of Saudi Arabia","volume":"6","author":"Basheikh MA","year":"2021","unstructured":"Basheikh MA, Balubaid H, Mohammed BA, et al. 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