{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:37:55Z","timestamp":1793090275233,"version":"4.5.0"},"reference-count":41,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K01AG086665"],"award-info":[{"award-number":["1K01AG086665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24AG072701"],"award-info":[{"award-number":["U24AG072701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Astrocytes become reactive in Alzheimer's disease (AD), and fluid markers of this response, including glial fibrillary acidic protein (GFAP) and chitinase-3-like protein 1 (YKL-40), increase across the AD continuum. However, it remains unclear whether astrocytic biomarker levels relate to preserved versus disrupted white matter (WM) integrity, and whether these relationships vary by amyloid-\u03b2 (A\u03b2) burden and apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) \u03b54 status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To examine associations of GFAP and YKL-40 with WM integrity, AD pathology, and memory across A\u03b2 and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 contexts.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed 52 dementia-free older adults from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with longitudinal diffusion tensor imaging and baseline cerebrospinal fluid (CSF) biomarkers. WM integrity was assessed using network-level stability and mean diffusivity within medial temporal lobe-associated networks. Baseline CSF GFAP, YKL-40, A\u03b2\n                      <jats:sub>1\u221242<\/jats:sub>\n                      , phosphorylated tau (p-tau181),\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 status, and episodic memory were examined. Findings were evaluated in an independent Stanford Alzheimer's Disease Research Center sample with plasma GFAP.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GFAP showed context-dependent associations with WM integrity and AD pathology. In A\u03b2-negative and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54-negative individuals, higher GFAP was associated with greater WM stability, lower mean diffusivity. In A\u03b2-positive and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54-positive individuals, higher GFAP was associated with higher p-tau18 rather than WM integrity. Higher YKL-40 was associated with reduced WM stability. In the validation cohort,\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      \u03b54 status moderated the association between plasma GFAP and WM integrity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Astrocytic biomarkers demonstrated relationships with WM integrity and AD pathology. GFAP appeared to reflect context-dependent astrocytic responses, whereas YKL-40 was consistently associated with WM disruption.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261485599","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:12:05Z","timestamp":1788883925000},"page":"155-168","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Stage-dependent associations of glial fibrillary acidic protein and chitinase-3-like protein 1 with white matter network integrity in Alzheimer's disease"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-0298-4052","authenticated-orcid":false,"given":"Oceanna Yueran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, CogT Lab, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Turnbull","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, CogT Lab, Stanford University, Palo Alto, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1945-0362","authenticated-orcid":false,"given":"Feng","family":"Vankee-Lin","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, CogT Lab, Stanford University, Palo Alto, CA, 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