{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:39:35Z","timestamp":1793090375419,"version":"4.5.0"},"reference-count":39,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Joint construction project of Henan Medical Science and Technology Research Program","award":["LHGJ20240484, LHGJ20230499"],"award-info":[{"award-number":["LHGJ20240484, LHGJ20230499"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peripheral lipid dysregulation has been implicated in neurodegeneration, but most studies have focused on single lipid measures within one dementia subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine whether a composite plasma lipid burden score (PLBS), derived from routine fasting lipid indices, differs across dementia with Lewy bodies (DLB), Alzheimer's disease (AD), and Parkinson's disease dementia (PDD) and whether it relates to baseline cognition and subsequent cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a longitudinal observational study including 227 patients with probable DLB (n\u2009=\u200965), AD (n\u2009=\u200979), or PDD (n\u2009=\u200983). PLBS was defined as the unweighted mean of z-standardized non-HDL cholesterol, remnant cholesterol, apolipoprotein B, apolipoprotein B\/apolipoprotein A1, LDL-C\/HDL-C, triglyceride\/HDL-C, and triglyceride-glucose index. Multivariable linear regression and linear mixed-effects models were used to examine associations with baseline cognition and annualized cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PLBS differed significantly across diagnoses and showed the clearest separation among lipid-related measures, with higher values in DLB and PDD than in AD. Higher PLBS was associated with poorer baseline global cognition and faster longitudinal decline. These associations appeared to be numerically more pronounced in DLB, with intermediate estimates in PDD and weaker estimates in AD in this exploratory analysis. Higher PLBS was linked to poorer attention and visuospatial\/executive performance and greater rapid cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An adverse plasma lipid burden profile is associated with worse cognition and faster decline across degenerative dementias, with the strongest effects in DLB. Routinely lipid-derived indices may complement existing approaches to longitudinal risk assessment. These findings require independent external validation and formal evaluation of predictive performance before clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261487127","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:27:24Z","timestamp":1789482444000},"page":"198-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of plasma lipid burden with cognitive performance and decline across dementia with Lewy bodies, Alzheimer's disease, and Parkinson's disease dementia"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1367-8550","authenticated-orcid":false,"given":"Zhou","family":"Su","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Henan Medical University, Weihui City, Xinxiang, Henan Province, China"},{"name":"Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein modification, Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengran","family":"Liu","sequence":"additional","affiliation":[{"name":"University of Bristol"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The Second Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kuai","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Henan Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Henan Medical University, Weihui City, Xinxiang, Henan Province, China"},{"name":"Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein modification, Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Henan Medical University, Weihui City, Xinxiang, Henan Province, China"},{"name":"Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein modification, Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuechang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Henan Medical University, Weihui City, Xinxiang, Henan Province, China"},{"name":"Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein modification, Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Henan Medical University, Weihui City, Xinxiang, Henan Province, China"},{"name":"Henan medical Key Laboratory of Neurology, Henan Joint International Laboratory of Neurorestoratology for Senile Dementia, Henan Key Laboratory of Neurorestoratology and Protein modification, Henan Medical University, Xinxiang, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Neurology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cangzhou People's Hospital, Cangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, 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