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These new models add to the growing portfolio of in vivo models of Down syndrome. In particular, the new Ts1Kei-APPswe\/PS1\n                    <jats:sup>dE9<\/jats:sup>\n                    model may be highly useful for the study and identification of novel treatment targets for late onset myoclonic epilepsy of Down syndrome. This seizure disorder is a common comorbidity of Down syndrome Alzheimer's disease affecting around half of all people with the condition and is associated with particularly adverse clinical outcomes.\n                  <\/jats:p>","DOI":"10.1177\/13872877261488873","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:10:37Z","timestamp":1789701037000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["New mouse models for Down syndrome Alzheimer's disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-3548","authenticated-orcid":false,"given":"Frances K.","family":"Wiseman","sequence":"first","affiliation":[{"name":"University College London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_3_3_2_2","unstructured":"The Centers for Disease Control and Prevention. 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