{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:26:47Z","timestamp":1793975207690,"version":"4.8.0"},"reference-count":18,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:p>\n                    Amyloid-related imaging abnormalities (ARIA) are a safety concern during lecanemab treatment for early Alzheimer's disease. We examined baseline cerebrospinal fluid amyloid-\u03b2 42 (A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ) in 97 lecanemab-treated patients; 11 developed ARIA. A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    was lower in ARIA cases than in non-ARIA cases (483.2\u2009\u00b1\u2009108.6 versus 667.4\u2009\u00b1\u2009185.4\u2005pg\/mL; p\u2009&lt;\u20090.001). ROC analysis yielded an AUC of 0.806 (95% CI, 0.670\u20130.919). A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    was also lower, whereas the A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    ratio was not significantly different and tau biomarkers were not higher. Lower A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    was associated with subsequent ARIA, but the internally derived cutoff requires external validation.\n                  <\/jats:p>","DOI":"10.1177\/13872877261488874","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T14:26:30Z","timestamp":1789482390000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Lower baseline cerebrospinal fluid amyloid-\u03b2 42 is associated with amyloid-related imaging abnormalities during real-world lecanemab treatment"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-7852","authenticated-orcid":false,"given":"Ryuichi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"},{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Tatsuno, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kashibayashi","sequence":"additional","affiliation":[{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Tatsuno, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fujita","sequence":"additional","affiliation":[{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Tatsuno, Hyogo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohsuke","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Dementia-Related Disease Medical Center, Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima, Tatsuno, Hyogo, Japan"},{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hashiramoto","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5300-8589","authenticated-orcid":false,"given":"Hisatomo","family":"Kowa","sequence":"additional","affiliation":[{"name":"Kobe University Graduate School of Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Hyogo Prefectural Rehabilitation Hospital at Nishi-Harima"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad188"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.3937"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005060"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-025-01912-6"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.149.2.351"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12316"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2009.01.027"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160722"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160865"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70015-7"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-61691-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100988"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae216"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0319-23.2024"}],"container-title":["Journal 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