{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T14:26:40Z","timestamp":1793975200555,"version":"4.8.0"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"European Research Area Network for Personalised Medicine - ERA PerMed","award":["ERAPERMED2021-184"],"award-info":[{"award-number":["ERAPERMED2021-184"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Communication about biomarkers and disclosure of Alzheimer's disease pathology is challenging. Earlier diagnosis has intensified this challenge, but evidence regarding communication of positive biomarker results for Alzheimer's disease to individuals with subjective cognitive decline remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The study aimed to investigate older adults\u2019 attitude toward knowing their risk of Alzheimer's disease, preferences regarding pre-biomarker counseling and diagnostic disclosure, and their views on the use of artificial intelligence in the diagnostic process when presented with a hypothetical scenario of subjective cognitive decline.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a cross-sectional nationwide questionnaire survey among an age-selected, sex- and residence-balanced sample from the Danish Civil Registration System where individuals with dementia, nursing home residency, or dementia medication use were excluded. An online questionnaire was sent to 30,000 participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 12,939 participants (aged 55\u201384 years, 53.3% female) answered at least one questionnaire item (response rate: 43.1%). More than two-thirds of the participants were interested in knowing their Alzheimer's disease risk status (76.4%). Information on treatment options, test reliability and risk prediction, along with written material, personal interaction and follow-up consultation, were rated as the most important topics. Simple graphical figures were preferred to accompany risk communication. Finally, 56.4% were positive toward use of artificial intelligence in diagnostics by physicians.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Older adults are interested in knowing their risk of developing Alzheimer's disease and trust physicians\u2019 use of artificial intelligence in the diagnostic process. Moreover, their preferences regarding information and methodology may help improve the current guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261489585","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:08:06Z","timestamp":1790604486000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Older adults\u2019 attitudes toward knowing their risk of Alzheimer's disease and preclinical diagnostic communication: A nationwide study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1066-1035","authenticated-orcid":false,"given":"Marie","family":"Bruun","sequence":"first","affiliation":[{"name":"Danish Dementia Research Centre"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8128-2294","authenticated-orcid":false,"given":"T.","family":"Rune Nielsen","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild","family":"Waldemar","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-4417","authenticated-orcid":false,"given":"Kristian Steen","family":"Frederiksen","sequence":"additional","affiliation":[{"name":"Danish Dementia Research Centre"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.01.001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00827-2"},{"key":"e_1_3_3_6_2","article-title":"Implications of preclinical Alzheimer\u2019s disease biomarker disclosure for US policy and society","volume":"14","author":"Erickson CM","year":"2022","unstructured":"Erickson CM, Gleason CE, Clark LR, et al. 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