{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:53:44Z","timestamp":1790924024459,"version":"4.1.0"},"reference-count":46,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Ministry of Health & Welfare","award":["RS-2025-02220492"],"award-info":[{"award-number":["RS-2025-02220492"]}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["IITP-2026-RS-2024-00438239"],"award-info":[{"award-number":["IITP-2026-RS-2024-00438239"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["RS-2024-00509257"],"award-info":[{"award-number":["RS-2024-00509257"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Whether spirometry-defined airflow limitation is independently associated with incident dementia and related disability burden remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between obstructive airflow limitation and incident dementia and to estimate dementia-related years lived with disability (YLDs) in a nationwide cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide population-based cohort study linking the Korea National Health and Nutrition Examination Survey (2014\u20132021) with national health insurance claims data. Adults aged \u226540 years with baseline spirometry and no prior dementia were included. Airflow limitation was defined as FEV1\/FVC &lt;0.70, with severity classified by percent-predicted FEV1. Inverse probability of treatment weighting balanced baseline covariates. Cox models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident dementia. Dementia-related YLDs were calculated using Global Burden of Disease Study weights.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During follow-up (2014\u20132023), 760 cases (4.79%) of dementia occurred among 15,854 adults. Normal pulmonary function was associated with lower dementia risk than airflow limitation (aHR, 0.62 [95% CI, 0.50\u20130.77]). Within the normal range, risk decreased across increasing FEV1\/FVC tertiles (T1 [lowest], 0.76 [0.60\u20130.96]; T2, 0.63 [0.49\u20130.81]; T3 [highest], 0.45 [0.34\u20130.59]). Among those with airflow limitation, risk increased with severity (mild: 1.32 [0.95\u20131.84]; moderate: 1.87 [1.41\u20132.46]). Greater severity was also associated with higher YLDs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Spirometry-defined airflow limitation was associated with higher dementia risk and greater disability burden, suggesting impaired pulmonary function as a potential factor in dementia risk stratification and brain health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261489594","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:08:21Z","timestamp":1790604501000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Spirometry-defined obstructive airflow limitation and risk of incident dementia: A nationwide cohort study in South Korea"],"prefix":"10.1177","author":[{"given":"Dongjin","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyeongmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejun","family":"Son","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Kyung Hee University"},{"name":"Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeon Seok","family":"Hwang","sequence":"additional","affiliation":[{"name":"Kyung Hee University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1628-9948","authenticated-orcid":false,"given":"Dong Keon","family":"Yon","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea"},{"name":"Kyung Hee University"},{"name":"Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf129"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.0976"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2024-004422"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4110\/in.2024.24.e20"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac113"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41533-023-00342-x"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1220OC"},{"key":"e_1_3_3_9_2","article-title":"Asthma amplifies dementia risk: evidence from CSF biomarkers and cognitive decline","volume":"8","author":"Nair AK","year":"2022","unstructured":"Nair AK, Van Hulle CA, Bendlin BB, et al. 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