{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:09:07Z","timestamp":1790784547033,"version":"4.1.0"},"reference-count":58,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acupuncture, with its extensive historical application and therapeutic effects, may serve as a viable method to modulate immune responses associated with Alzheimer's disease immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the effects of stimulating the ST36 acupoint before vaccine injection in C57BL\/6J mice and to determine how acupuncture influences immune responses and its potential immunomodulatory effects associated with a dendritic-cell-based amyloid-\u03b2 (A\u03b2) vaccine.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Flow cytometry for immune cell profiling, antibody levels, immunoglobulin isotyping, cytokine expression profiling, western blotting, and immunohistochemistry were performed to evaluate immunological and neuroimmune responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Acupuncture modulated antibody production, influenced Th1\/Th2 immune responses, and may influence BDNF\/TrkB-associated neurotrophic signaling following vaccination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that acupuncture may modulate immune and neurotrophic signaling responses associated with dendritic-cell-based A\u03b2 vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261490135","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:43:17Z","timestamp":1790682197000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of acupuncture in the dendritic cell vaccine against Alzheimer's disease"],"prefix":"10.1177","author":[{"given":"Yuzhu","family":"Hong","sequence":"first","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Shen","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghufran","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Regmi","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Lin","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningyi","family":"Guo","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Hearn","sequence":"additional","affiliation":[{"name":"University of South Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3599-6859","authenticated-orcid":false,"given":"Darrell","family":"Sawmiller","sequence":"additional","affiliation":[{"name":"MegaNano Diagnostics, Tampa, FL, USA"},{"name":"MegaNano Biotechnology, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6298-8761","authenticated-orcid":false,"given":"Chuanhai","family":"Cao","sequence":"additional","affiliation":[{"name":"University of South Florida"},{"name":"MegaNano Diagnostics, Tampa, FL, USA"},{"name":"MegaNano Biotechnology, Tampa, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.09.020310"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1179573520907397"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160612"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-019-0063-8"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57078"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/alzrt220"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines10091527"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-022-00292-3"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126442"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4161\/hv.24696"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.09.008"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/32588"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030590"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.954936"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00257-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2010.06.004"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41514-024-00144-6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.064"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200413"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.05.017"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049468"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9926445"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.813748"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1147718"},{"key":"e_1_3_3_26_2","first-page":"36","article-title":"Brain-derived neurotrophic factor signaling pathway: modulation by acupuncture in telomerase knockout mice","volume":"21","author":"Lin D","year":"2015","unstructured":"Lin D, Wu Q, Lin X, et al. Brain-derived neurotrophic factor signaling pathway: modulation by acupuncture in telomerase knockout mice. Altern Ther Health Med 2015; 21: 36\u201346.","journal-title":"Altern Ther Health Med"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2017-011496"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1012033"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9371-2"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3479"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.6159"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2032057"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.3390\/antib8040057"},{"key":"e_1_3_3_34_2","unstructured":"Vaschetto L. Antibodies: structure types and therapeutic roles. News Medical 2025. https:\/\/www.news-medical.net\/life-sciences\/Types-of-Antibodies.aspx (accessed 2 May 2025)."},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S436907"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120861"},{"key":"e_1_3_3_37_2","volume-title":"Why are women more likely to develop Alzheimer\u2019s disease?","author":"Budson AE.","year":"2022","unstructured":"Budson AE. Why are women more likely to develop Alzheimer\u2019s disease? Harvard Health Publishing, 2022. https:\/\/www.health.harvard.edu\/blog\/why-are-women-more-likely-to-develop-alzheimers-disease-202201202672 (accessed 2 May 2026)."},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000073623.84147.A8"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.937486"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14061117"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1517\/14712590902828285"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21523"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00163-y"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.21037\/hbsn-2021-25"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1645906"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00924"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30555"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2018.11.005"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2018.10.076"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.08.008"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2011.00732.x"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00035.2015"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-018-0726-5"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401837"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170111141915"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/7027949"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.11.018"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12143"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161629"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261490135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261490135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261490135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:47:21Z","timestamp":1790783241000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261490135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":58,"alternative-id":["10.1177\/13872877261490135"],"URL":"https:\/\/doi.org\/10.1177\/13872877261490135","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"13872877261490135"}}