{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:52:08Z","timestamp":1791568328054,"version":"4.3.4"},"reference-count":51,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diacylglycerol kinase theta (DGK\u03b8) is an enzyme involved in lipid signaling pathways and has been implicated in Alzheimer's disease (AD). DGK\u03b8 plays a crucial role in regulating diacylglycerol and phosphatidic acid levels, which are important for neuronal function and survival. Dysregulation of DGK\u03b8 leads to abnormal lipid signaling, contributing to neuroinflammation, synaptic dysfunction, and neurodegeneration\u2014hallmarks of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the involvement of DGK\u03b8 in AD by measuring DGK\u03b8 levels as a function of age in the brains of APP\/PS1 mice and associating its changes with key AD neuropathological markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>To investigate the role of DGK-\u03b8 in AD, brain tissues from young and aged APP\/PS1 transgenic and wild-type mice were analyzed using western blot, immunohistochemistry, and Pearson correlation analyses to establish relationships between protein expression levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We found that DGK\u03b8 levels were higher in older, but not in younger, APP\/PS1 mice compared to age-matched controls. Notably, there was a positive correlation between DGK\u03b8 levels, A\u03b2\n                      <jats:sub>42<\/jats:sub>\n                      levels, and astrogliosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that DGK\u03b8 may play an important role in AD and that its modulation could represent a potential therapeutic strategy for this insidious disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261490813","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:20:04Z","timestamp":1791397204000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alterations in diacylglycerol kinase \u03b8 define early pathological features of Alzheimer's disease in a mouse model"],"prefix":"10.1177","author":[{"given":"Marika","family":"Lanza","sequence":"first","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Basilotta","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Adriana","family":"Scuderi","sequence":"additional","affiliation":[{"name":"Genetics and Pharmacogenetics Unit, \u201cGaetano Martino\u201d University Hospital, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Giovani","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Caccamo","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0552-1396","authenticated-orcid":false,"given":"Giovanna","family":"Casili","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvatore","family":"Oddo","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Esposito","sequence":"additional","affiliation":[{"name":"University of Messina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23094962"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-02787-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2019.01.005"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.324824"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-04240-z"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2019.100688"},{"key":"e_1_3_3_9_2","first-page":"41619","article-title":"Dual regulation of diacylglycerol kinase (DGK)-theta: polybasic proteins promote activation by phospholipids and increase substrate affinity","volume":"287","author":"Tu-Sekine B and Raben DM.","year":"2012","unstructured":"Tu-Sekine B and Raben DM. 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