{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:53:34Z","timestamp":1791204814258,"version":"4.1.0"},"reference-count":37,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Yunnan province innovation team of prevention and treatment for brain diseases with acupuncture and Tuina","award":["NO.202405AS350007"],"award-info":[{"award-number":["NO.202405AS350007"]}]},{"name":"Yunnan Provincial Department of Science and Technology","award":["NO.202401AZ070001-018"],"award-info":[{"award-number":["NO.202401AZ070001-018"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The association between waist-to-height ratio (WHtR) and Alzheimer's disease (AD) remains unclear in the general population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to investigate the relationship between WHtR and AD using data from the nationally representative National Health and Nutrition Examination Survey (NHANES).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included participants aged \u226545 years from NHANES. Weighted multivariable logistic regression, restricted cubic spline (RCS), subgroup, and sensitivity analyses were performed to evaluate the association between WHtR (scaled by 10) and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher WHtR was significantly associated with greater odds of AD after adjustment for potential confounders (OR = 1.30, 95% CI: 1.18\u20131.42,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Significant interactions were observed for age (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for interaction = 0.017) and physical activity (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for interaction = 0.02). RCS analysis revealed a significant nonlinear U-shaped association between WHtR and AD (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      for nonlinearity = 0.005), with the lowest odds observed at a WHtR value of 5.46 on the 10-fold scale. Sensitivity analyses showed generally consistent results.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Higher WHtR was significantly associated with greater odds of AD among middle-aged and older adults. A nonlinear U-shaped association was also observed, suggesting that both lower and higher WHtR levels may be associated with increased odds of AD. Further prospective studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261490818","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:01:51Z","timestamp":1790827311000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nonlinear association between waist-to-height ratio and Alzheimer's disease among middle-aged and older adults: A cross-sectional study from NHANES"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4447-4369","authenticated-orcid":false,"given":"Bei","family":"Li","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianai","family":"Shi","sequence":"additional","affiliation":[{"name":"The second Affiliated Hospital of Yunnan University of Chinese Medicine, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meidi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation, Zhijiang Hospital of Traditional Chinese Medicine, Yichang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijing","family":"Liu","sequence":"additional","affiliation":[{"name":"Yunnan University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(24)00264-X"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.653651"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.12.016"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-643"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2023.1294420"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30084-4"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.343891"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.7570\/jomes22058"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010159"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2024.103042"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03817-4"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2023.06.029"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000218093"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-025-01660-3"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2024.2339729"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70785"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2174\/0115672050372100250512054404"},{"key":"e_1_3_3_20_2","first-page":"1","article-title":"National health and nutrition examination survey: analytic guidelines, 1999-2010","volume":"2","author":"Johnson CL","year":"2013","unstructured":"Johnson CL, Paulose-Ram R, Ogden CL, et al. 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