{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:09Z","timestamp":1791895569821,"version":"4.3.4"},"reference-count":58,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) raises global concern with its impact on daily living. Anti-amyloid therapy (AAT) are specific treatments used in mild cognitive impairment (MCI) and mild dementia stage of AD (mild AD). Severe cerebral small vessel disease (SVD) lesions such as microbleeds, superficial siderosis, lacunes, white matter hyperintensities are listed as exclusions criteria for AAT. In Thailand, there is no prevalence study of SVD lesions specifically in these patient groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The purpose of this study is to report the prevalence of SVD burdens which are excluded in AAT, in MCI and mild AD patients in Thailand.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study was carried out at Memory Clinic in King Chulalongkorn Memorial Hospital. Patients with amnestic MCI and mild AD were diagnosed using clinical criteria, cognitive tests and brain MRI. Visual rating scales were used to evaluate SVD burden based on STRIVE-2 criteria. Baseline characteristics and cognitive tests were retrieved from electronic medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study involving 102 patients, 73.5% had MCI, and 26.5% had mild AD. Twenty-one individuals (20.6%) had either more than 4 microbleeds, more than 2 lacunes, or Fazekas score of 3. There was no evidence of superficial siderosis. Individuals without microbleeds had a higher TMSE score (25.4 versus 23.5; p\u2009=\u20090.009).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Among patients with MCI and mild AD, 20.6% met the exclusion criteria for AAT, in part of SVD lesions. These findings provide important information for evaluating the cost-effectiveness of AAT, which become a treatment option for Thai AD patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261493065","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:47:37Z","timestamp":1791632857000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and impact of cerebral small vessel lesions in mild cognitive impairment and mild dementia due to Alzheimer's disease patients in memory clinic: Preparation for anti-amyloid therapy in Thailand"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7306-7271","authenticated-orcid":false,"given":"Thachamai","family":"Smitasiri","sequence":"first","affiliation":[{"name":"Chulalongkorn University"},{"name":"King Chulalongkorn Memorial Hospital"},{"name":"Chulalongkorn University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8338-4649","authenticated-orcid":false,"given":"Thanakit","family":"Pongpitakmetha","sequence":"additional","affiliation":[{"name":"King Chulalongkorn Memorial Hospital"},{"name":"Chulalongkorn University"},{"name":"Chulalongkorn University"},{"name":"King Chulalongkorn Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-1372","authenticated-orcid":false,"given":"Sekh","family":"Thanprasertsuk","sequence":"additional","affiliation":[{"name":"Chulalongkorn University"},{"name":"King Chulalongkorn Memorial Hospital"},{"name":"Chulalongkorn University"},{"name":"Chulalongkorn University"},{"name":"King Chulalongkorn Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuttachai","family":"Likitjaroen","sequence":"additional","affiliation":[{"name":"King Chulalongkorn Memorial Hospital"},{"name":"Chulalongkorn University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,10]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32205-4"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000515676"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2018.10.009"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2020.06.007"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph14020110"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-140843"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-023-00637-0"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100150"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01053-8"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70060-7"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad188"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00813-8"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare11010032"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231810490"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00927"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S200490"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(23)00131-X"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210535.20297.ae"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000285"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.04.023"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318221ad36"},{"key":"e_1_3_3_25_2","first-page":"11","article-title":"Cerebral microbleeds: association with other small vessel diseases, risk factors and cognition in Thai dementia patients","volume":"34","author":"Senanarong V","year":"2018","unstructured":"Senanarong V, Pimolsri C, Danchaivijitr N. Cerebral microbleeds: association with other small vessel diseases, risk factors and cognition in Thai dementia patients. Thai J Neurol 2018; 34: 11\u201320.","journal-title":"Thai J Neurol"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00066-1"},{"key":"e_1_3_3_27_2","volume-title":"Clinical practice guideline for dementia","author":"Rojana-udomsart A","year":"2020","unstructured":"Rojana-udomsart A, Khieukhajee J, Tantirittisak T. Clinical practice guideline for dementia. Neurological Institute of Thailand, Department of Medical Service, Ministry of Public Health, Thailand, 2020."},{"key":"e_1_3_3_28_2","first-page":"359","article-title":"Thai mental state examination (TMSE)","author":"Train the Brain Forum Committee","year":"1993","unstructured":"Train the Brain Forum Committee. Thai mental state examination (TMSE). Siriraj Hosp Gaz 1993; 45: 359\u2013374.","journal-title":"Siriraj Hosp Gaz"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1159\/000517822"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868807"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310090"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009141"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1159\/000509731"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0204313"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200204000-00002"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12877-022-03456-y"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2021.100010"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/131216"},{"key":"e_1_3_3_39_2","first-page":"8","article-title":"White matter lesions in community dwelling Thai elders with MCI and Dementia","volume":"35","author":"Senanarong V","year":"2019","unstructured":"Senanarong V, Poungvarin N, Chawalparit O, et al. White matter lesions in community dwelling Thai elders with MCI and Dementia. Thai J Neurol 2019; 35: 8\u201316.","journal-title":"Thai J Neurol"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-019-1422-3"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2019.101250"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201801-0204PP"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2024.145"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182452928"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000179092.59909.42"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.698035"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01309-6"},{"key":"e_1_3_3_48_2","first-page":"35","article-title":"Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer\u2019s disease: a combined positron emission tomography\/magnetic resonance imaging study","volume":"9","author":"Sone D","year":"2017","unstructured":"Sone D, Imabayashi E, Maikusa N, et al. Regional tau deposition and subregion atrophy of medial temporal structures in early Alzheimer\u2019s disease: a combined positron emission tomography\/magnetic resonance imaging study. Alzheimers Dement 2017; 9: 35\u201340.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.01.002"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-023-01244-8"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011050"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.24843\/MU.2023.V12.i12.P07"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.906519"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.3233\/ADR-220059"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14138"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13022"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2024.0550"},{"key":"e_1_3_3_58_2","article-title":"Real-world\u201d eligibility for anti-amyloid treatment in a tertiary memory clinic setting","volume":"21","author":"Vigneswaran S","year":"2025","unstructured":"Vigneswaran S, Vijverberg EG, Barkhof F, et al. Real-world\u201d eligibility for anti-amyloid treatment in a tertiary memory clinic setting. Alzheimers Dement 2025; 21: e70375.","journal-title":"Alzheimers Dement"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-333468"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261493065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261493065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261493065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:54:29Z","timestamp":1791892469000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261493065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":58,"alternative-id":["10.1177\/13872877261493065"],"URL":"https:\/\/doi.org\/10.1177\/13872877261493065","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"article-number":"13872877261493065"}}