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Safety was assessed by neurological examinations and brain magnetic resonance imaging (MRI). Exploratory outcomes included the Trail Making Test-Black &amp; White (TMT-B&amp;W) parts A and B, Attention Questionnaire Scale (AQS), Korean version of Quality of Life (KQoL), Mini-Mental State Examination (MMSE), and Neuropsychiatric Inventory (NPI). Resting-state functional MRI was analyzed in an exploratory subset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No severe adverse events occurred, and post-treatment MRI showed no intracerebral hemorrhage, microbleeding, or brain edema. Completion times decreased on TMT-B&amp;W part A (105.3\u2009\u00b1\u200963.3 versus 84.2\u2009\u00b1\u200946.6\u2005s, p\u2009=\u20090.012) and part B (280.1\u2009\u00b1\u2009139.9 versus 212.8\u2009\u00b1\u200959.7\u2005s, p\u2009=\u20090.038). NPI scores also decreased (9.8\u2009\u00b1\u200914.7 versus 4.5\u2009\u00b1\u20098.8, p\u2009=\u20090.006). KQoL, AQS, and MMSE did not change significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Repeated LIUS over 4 weeks was feasible and well tolerated in amyloid PET-positive early AD. Exploratory changes in executive function and neuropsychiatric symptoms were observed; however, the single-arm design precludes causal inference. Randomized, sham-controlled studies are warranted to determine the therapeutic potential of LIUS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261493067","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:45:06Z","timestamp":1790682306000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Feasibility and safety of repeated low-intensity ultrasound in amyloid PET-positive early Alzheimer's disease: A prospective pilot study"],"prefix":"10.1177","author":[{"given":"Bo-Yong","family":"Park","sequence":"first","affiliation":[{"name":"Korea University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Gyeonggi-do, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Young","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology"},{"name":"Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Korea Institute of Science and Technology"},{"name":"Division of Bio-Medical Science and Technology, KIST School, Korea University of Science and Technology, Seoul, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Hallym University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk Yun","family":"Kang","sequence":"additional","affiliation":[{"name":"Hallym University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Cho","sequence":"additional","affiliation":[{"name":"Hallym University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-2359","authenticated-orcid":false,"given":"Jaeho","family":"Kim","sequence":"additional","affiliation":[{"name":"Hallym University College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9101-5704","authenticated-orcid":false,"given":"SangYun","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul National University Bundang Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3505"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70291-0"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-00735-y"},{"key":"e_1_3_3_5_2","first-page":"369808","article-title":"Alzheimer\u2019s disease and the amyloid cascade hypothesis: a critical review","volume":"2012","author":"Reitz C.","year":"2012","unstructured":"Reitz C. 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