{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:53:45Z","timestamp":1792068825666,"version":"4.4.0"},"reference-count":26,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K07401"],"award-info":[{"award-number":["22K07401"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blood-based biomarker testing in primary care could contribute to the early diagnosis of Alzheimer's disease. The usefulness of using blood-based biomarker in the primary care has evaluated, but their psychological impact has not been examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The primary objective of this study is to investigate the psychological impact of disclosing results to patients and evaluate the changes in confidence of diagnoses by physicians. As a secondary objective, we compare the psychological impact with positron emission tomography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included adults aged \u226550 years with suspected mild cognitive impairment or mild dementia. In total, 97 were analyzed in this study. All participants underwent blood-based biomarker testing and the results were disclosed by primary care physicians or specialists. Psychological impact was measured using the Impact of Event Scale\u2013Revised 1 week after disclosure. Physician diagnostic confidence, changes in diagnosis and management actions were also recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nineteen participants had negative blood-based biomarker results but positive PET results. The Impact of Event Scale\u2013Revised scores were low after blood-based biomarker disclosure and did not differ by health care provider. Blood-based biomarker results prompted changes in diagnosis in 41.9% of cases. The diagnostic confidence increased after disclosure of the blood-based biomarker. Physicians reported a moderate\/strong impact on management in 81.5% of cases after the disclosure of blood-based biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, blood-based biomarker result disclosure to patients with mild cognitive impairment had minimal short-term psychological burden and informed clinical decisions. These findings support the integration of blood-based biomarker testing into dementia care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261494606","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T14:28:30Z","timestamp":1791815310000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Psychological impact of the use of blood-based biomarkers for mild cognitive impairment in primary care"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9416-9867","authenticated-orcid":false,"given":"Takuya","family":"Ataka","sequence":"first","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Kimura","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5834-594X","authenticated-orcid":false,"given":"Temmei","family":"Ito","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Shimadzu Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9730-3339","authenticated-orcid":false,"given":"Teruaki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Shimadzu Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd, Bunkyo-ku, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Iwamoto","sequence":"additional","affiliation":[{"name":"Shimadzu Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etsuro","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Oita University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13809"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6157"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2024-333468"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2019.07.005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature25456"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-01946-y"},{"key":"e_1_3_3_12_2","article-title":"Alzheimer\u2019s association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer\u2019s disease and related disorders (DETeCD-ADRD): executive summary of recommendations for primary care","volume":"21","author":"Atri A","year":"2025","unstructured":"Atri A, Dickerson BC, Clevenger C, et al. Alzheimer\u2019s association clinical practice guideline for the diagnostic evaluation, testing, counseling, and disclosure of suspected Alzheimer\u2019s disease and related disorders (DETeCD-ADRD): executive summary of recommendations for primary care. 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Plasma amyloid beta biomarkers predict amyloid positivity and longitudinal clinical progression in mild cognitive impairment. 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