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While existing reviews often focus on isolated processes, they frequently lack an integrative analysis of the \u201cferroptosis\u2013lipid\u2013neuroinflammation axis\u201d as a systemic pathological core. This review specifically addresses this gap by proposing a unified mechanistic framework for neuronal injury, synaptic dysfunction, and immunometabolic remodeling in AD, centered on this tripartite axis. We comprehensively summarize how key pathways involving glutathione peroxidase 4 (GPX4), ferroptosis suppressor protein 1 (FSP1), coenzyme Q10 (CoQ10), the cystine\/glutamate antiporter system Xc\n                    <jats:sup>\u2212<\/jats:sup>\n                    , solute carrier family 7 member 11 (SLC7A11), AMP-activated protein kinase (AMPK), nuclear factor erythroid 2-related factor 2 (NRF2), and N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) regulation shape neuroinflammation within this context. Furthermore, we explore how advanced methodologies, including spatial omics, single-cell transcriptomics, organoid models, and engineered exosome methods, are instrumental in elucidating regional specificity, optimal intervention windows, and targeted delivery strategies for modulating this iron-lipid-inflammation interplay. This axis functions as a pathological amplifier, linking metabolic, oxidative, immune, and structural dysfunctions. Its systemic reprogramming offers a new paradigm for AD subtyping, biomarker discovery, and multitarget interventions, thereby overcoming the limitations of traditional amyloid-\u03b2\/tau-centric approaches. This review integrates literature published up to the submission date, ensuring the inclusion of the latest mechanistic insights and translational advances in the ferroptosis\u2013lipid metabolism\u2013neuroinflammation axis.\n                  <\/jats:p>","DOI":"10.1177\/13872877261495962","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:51:37Z","timestamp":1791910297000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The ferroptosis-lipid metabolism-neuroinflammation axis in Alzheimer's disease: A review of mechanistic interplay and therapeutic implications"],"prefix":"10.1177","author":[{"given":"Tao","family":"Zhu","sequence":"first","affiliation":[{"name":"College of Pharmacy, Guilin Medical University, Guilin, Guangxi, 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