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We examined the relationship between cardiac output and cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease pathologies in 153 participants from the Vanderbilt Memory and Aging Project. Linear regression and linear mixed effects regression models related baseline cardiac output, assessed using echocardiogram, to CSF amyloid-\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    (A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    ), A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    , and phosphorylated tau-181 cross-sectionally and longitudinally. Cardiac output interacted with sex on A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    levels longitudinally. Lower cardiac output was associated with lower A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    over time in women but not men. This may reflect cerebral A\u03b2 accumulation or a more general change in A\u03b2 production.\n                  <\/jats:p>","DOI":"10.1177\/13872877261497236","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:52:10Z","timestamp":1792147930000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Lower cardiac output is associated with longitudinal decreases in cerebrospinal fluid amyloid-\u03b242, a core Alzheimer's disease biomarker, in women but not men"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7015-7957","authenticated-orcid":false,"given":"Amalia J.","family":"Peterson","sequence":"first","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunyi","family":"Sun","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly R.","family":"Pechman","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-6500","authenticated-orcid":false,"given":"Francis E.","family":"Cambronero","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth E.","family":"Moore","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Mass General Brigham"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3377-7014","authenticated-orcid":false,"given":"Timothy J.","family":"Hohman","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Sahlgrenska University Hospital"},{"name":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden"},{"name":"Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK"},{"name":"UK Dementia Research Institute at UCL, London, UK"},{"name":"Hong Kong Center for Neurodegenerative Diseases, InnoHK, Hong Kong, China"},{"name":"Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA"},{"name":"Centre for Brain Research, Indian Institute of Science, Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8245-0587","authenticated-orcid":false,"given":"Angela L.","family":"Jefferson","sequence":"additional","affiliation":[{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"},{"name":"Vanderbilt University Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012438"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004707"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.120.311909"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.07.078"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2022.0088"},{"key":"e_1_3_3_7_2","first-page":"49","article-title":"Variations of cardiac performance and inotropism in healthy postmenopausal women treated with estroprogestin replacement therapy","volume":"6","author":"Gallinelli A","year":"1999","unstructured":"Gallinelli A, Angioni S, Matteo ML, et al. 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