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Transcranial alternating current stimulation (tACS) can improve cognitive function by modulating neural oscillations. While tACS shows therapeutic potential for dementia, its preventive effects remain unknown. Because tACS has long-lasting modulatory effects, we propose that these offline effects may help prevent dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aims to determine whether pre-administered 40\u202fHz tACS prevents scopolamine-induced impairment of electroencephalogram (EEG) activity and spatial cognition. Scopolamine induces cholinergic dysfunction in animal models, mimicking AD-related behavioral and EEG abnormalities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Scopolamine (3\u2005mg\/kg, i.p.) was administered to induce a mouse model of dementia. Prior to induction, tACS targeting the prefrontal cortex (PFC) and\/or hippocampus (Hip) was performed for five days (40\u2005Hz, 300\u2005\u03bcA, 20\u2005min\/day). EEG activity was recorded from the PFC and Hip during spontaneous and task-related (Y-maze) states. In addition, spatial memory was evaluated using the Barnes maze test, and general activity including locomotion and anxiety was evaluated using the open field test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Scopolamine reduced spontaneous EEG activity in gamma frequency band and task-related PFC EEG activity across multiple frequency bands. Prior Hip tACS prevented these EEG reductions. Behaviorally, scopolamine induced spatial memory deficits and increased locomotion and anxiety-like behaviors. Notably, dual-site tACS reversed memory impairment and PFC tACS reduced locomotion. In addition, tACS had little effect on anxiety.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Prior gamma tACS exerts region-specific protection against scopolamine-induced EEG and behavioral impairments, providing first evidence for its potential as a preventive strategy for dementia-related deficits.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261497298","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:04Z","timestamp":1791910504000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Gamma transcranial alternating current stimulation prevents scopolamine-induced damage to EEG activity and spatial memory"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6479-8684","authenticated-orcid":false,"given":"Yuan","family":"Yuan","sequence":"first","affiliation":[{"name":"Kunming University of Science & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Xing","sequence":"additional","affiliation":[{"name":"Kunming University of Science & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Geriatric Psychiatry, Shenzhen Mental Health Center\/Shenzhen Kangning Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuangfei","family":"Chen","sequence":"additional","affiliation":[{"name":"Kunming University of Science & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fu","sequence":"additional","affiliation":[{"name":"Kunming University of Science & Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_3_3_2_2","volume-title":"World Alzheimer Report 2018: the state of the art of dementia research: new frontiers","author":"Patterson C.","year":"2018","unstructured":"Patterson C. 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