{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T17:40:11Z","timestamp":1792345211944,"version":"4.4.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronotype may affect neurophysiology, but whether its association with dementia persists independent of other sleep traits remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine associations of chronotype with incident dementia subtypes and potential modification by metabolic and social factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In 443,906 dementia-free participants, Cox models estimated dementia risk after adjustment for sociodemographic, lifestyle, clinical, apolipoprotein E (\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      ) genotype, and sleep-related factors. We tested baseline interactions and robustness using multiple imputation, competing-risk models, and landmark analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a mean follow-up of 12.5 years, 6355 incident dementia cases were documented. Evening chronotype was associated with a small increased risk of all-cause dementia compared with morning types (HR, 1.07; 95% CI, 1.01\u20131.14). This association was observed primarily in \u201cother dementias\u201d (HR, 1.12; 1.04\u20131.21), with no significant association with Alzheimer's disease or vascular dementia (VaD).<\/jats:p>\n                    <jats:p>Exploratory subgroup analyses identified two interactions that remained significant after false discovery rate (FDR) correction: social visit frequency for all-cause dementia and napping for VaD (FDR-adjusted p for interaction is 0.024 for both). Evening chronotype was associated with higher all-cause dementia risk among participants reporting infrequent social visits and with higher VaD risk among those reporting usual napping.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Evening chronotype was associated with a small increase in the hazard of all-cause dementia after multivariable adjustment. Given the modest magnitude and observational design, evening chronotype may be considered a potential risk marker rather than an independent or causal risk factor. These findings require independent replication.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261498357","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:54:51Z","timestamp":1792148091000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Evening chronotype and incidence of all-cause dementia and subtypes after accounting for other sleep traits: A prospective cohort study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5473-4320","authenticated-orcid":false,"given":"Jiaying","family":"Li","sequence":"first","affiliation":[{"name":"The Chinese University of Hong Kong","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Woo","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijian","family":"Yang","sequence":"additional","affiliation":[{"name":"The Chinese University of Hong Kong","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengjie","family":"Ye","sequence":"additional","affiliation":[{"name":"Guangzhou Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxin","family":"Li","sequence":"additional","affiliation":[{"name":"Johns Hopkins University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/neuroglia6010001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47070547"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30461-7"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2022.101108"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/07420528.2012.741171"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjph-2024-001000"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101713"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100168"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz849"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000209141"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545979"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1008820"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym276"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29307-3"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955"},{"key":"e_1_3_3_17_2","article-title":"Hippocampal volumes in UK Biobank are associated with APOE only in older adults","volume":"16","author":"Chaloemtoem A","year":"2024","unstructured":"Chaloemtoem A, Thornton V, Chang Y, et al. 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Alzheimers Dement (Amst) 2024; 16: e70024.","journal-title":"Alzheimers Dement (Amst)"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10742-022-00280-0"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojs.2015.57075"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-019-00499-1"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx148"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2003.04.009"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114438"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2015.04.006"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2017.01.019"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19120"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.1859"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261498357","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/13872877261498357","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/13872877261498357","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T16:47:17Z","timestamp":1792342037000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/13872877261498357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,16]]},"references-count":27,"alternative-id":["10.1177\/13872877261498357"],"URL":"https:\/\/doi.org\/10.1177\/13872877261498357","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,16]]},"article-number":"13872877261498357"}}