{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T14:41:04Z","timestamp":1792334464715,"version":"4.4.0"},"reference-count":41,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P20GM125526-01A1"],"award-info":[{"award-number":["1P20GM125526-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AG027060"],"award-info":[{"award-number":["5R01AG027060"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AG038707"],"award-info":[{"award-number":["5R01AG038707"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5U01AG019349-05"],"award-info":[{"award-number":["5U01AG019349-05"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["N01-HC-05102"],"award-info":[{"award-number":["N01-HC-05102"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between late-life blood pressure and incident dementia (including Alzheimer's disease and vascular dementia) remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To examine whether late-life blood pressure is associated with incidence of dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed 2649 participants aged 71 to 93 years without prevalent dementia at baseline in a prospective cohort of Japanese-American men (the Kuakini Honolulu Heart Program). Diagnosis of dementia was conducted based on standardized protocols and participants were followed for up to 20 years. Cox proportional hazards models were applied to estimate hazard ratios (HR) for incident dementia across blood pressure categories, adjusting for demographic, medical, lifestyle, and genetic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During follow-up, 716 cases of incident dementia were identified (519 cases of Alzheimer's disease and 88 cases of vascular dementia). After adjustment, high late-life systolic blood pressure (\u2265160\u2005mmHg) was associated with a lower risk of Alzheimer's disease [HR 0.72 (95% confidence interval: 0.56\u20130.93)] and a higher risk of vascular dementia [HR 1.95 (95% confidence interval: 1.03\u20133.68)] compared to the reference (120 to &lt;140\u2005mmHg) group. The protective effect of high late-life systolic blood pressure (\u2265160\u2005mmHg) on Alzheimer's disease was seen only in participants with the protective version of the\n                      <jats:italic toggle=\"yes\">FOXO3<\/jats:italic>\n                      genotype. No significant associations were found between diastolic blood pressure and incidence of dementia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>High late-life systolic blood pressure was associated with a protective effect against Alzheimer's disease, after adjusting for confounders, including the FOXO3 longevity genotype, and an increased risk of vascular dementia in older men aged over 71 years.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261498372","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:55:15Z","timestamp":1792148115000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between late-life blood pressure and incident dementia in older men: The Kuakini Honolulu-Asia aging study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3075-3823","authenticated-orcid":false,"given":"Yuki","family":"Ogawa","sequence":"first","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]},{"name":"Nara Medical University","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Chen","sequence":"additional","affiliation":[{"name":"Deparment of Research, Kuakini Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Webster","family":"Ross","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Donlon","sequence":"additional","affiliation":[{"name":"Deparment of Research, Kuakini Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina","family":"Fujikami","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Takenaka","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley","family":"Willcox","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]},{"name":"Deparment of Research, Kuakini Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Masaki","sequence":"additional","affiliation":[{"name":"University of Hawaii at Manoa","place":["USA"]},{"name":"Deparment of Research, Kuakini Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,16]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159485"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000517"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.128744"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.178962"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.147389"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000132475.32317.bb"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(00)00096-8"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530230032026"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad112"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2007.01233.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2018.05.029"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000098934.18300.BE"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.09.007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.182204"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000133128.42462.ef"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90608-X"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.8.1175"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.319951"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03540120033030"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720512801322618"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610294001602"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"e_1_3_3_24_2","volume-title":"Diagnostic and statistical manual of mental disorders, Revised Third Edition","author":"American Psychiatric Association","year":"1987","unstructured":"American Psychiatric Association. 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