{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:35:48Z","timestamp":1793025348529,"version":"4.5.0"},"reference-count":57,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01 AG070088"],"award-info":[{"award-number":["R01 AG070088"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Odor identification impairment is an early feature of Alzheimer's disease and predicts memory decline, but its microstructural basis remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate FD, a semi-quantitative synthetic magnetic resonance imaging (MRI)\u2013derived Fluid-Attenuated Inversion Recovery (FLAIR)\u2013Double Inversion Recovery (DIR) contrast, against myelin volume fraction (MVF) in olfactory\u2013limbic brain regions of patients diagnosed with mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Sixteen healthy controls (HC) and 17 individuals diagnosed with MCI completed olfactory and cognitive testing and underwent 3T MRI using a QALAS sequence. MVF maps were generated and FD was computed as (FLAIR \u2212 DIR)\/FLAIR. Group differences were examined in olfactory\u2013limbic gray matter and associated white-matter tracts, and voxel-wise regression assessed FD\u2013odor identification associations, including models adjusted for voxel-wise MVF. Region of interest and voxel-wise analyses were exploratory and largely uncorrected for multiple comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with HC, MCI showed lower FD across olfactory\u2013limbic gray matter and white-matter pathways, including hippocampus, amygdala, orbitofrontal cortex, thalamus and corpus callosum, whereas MVF differences were more limited. Better odor identification was associated with higher FD in hippocampal\/parahippocampal regions and insula, persisting after MVF adjustment. MVF showed positive associations in the right parahippocampal gyrus, left thalamus and genu of the corpus callosum. In an exploratory secondary analysis reported in the Supplemental Material, FD-based classification exceeded chance but was not separable from age alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>FD is a semi-quantitative relaxation-contrast metric showing regional patterns partially distinct from MVF. These exploratory findings require replication in larger, demographically matched, biomarker-confirmed cohorts before FD can be regarded as a marker of early olfactory\u2013limbic microstructural change in MCI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/13872877261498397","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:12:52Z","timestamp":1792815172000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["An exploratory synthetic MRI-derived FLAIR\u2013DIR contrast in olfactory\u2013limbic regions in mild cognitive impairment"],"prefix":"10.1177","author":[{"given":"Anupa","family":"Ekanayake","sequence":"first","affiliation":[{"name":"Pennsylvania State University College of Medicine","place":["USA"]},{"name":"Pennsylvania State University College of 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