{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T18:48:39Z","timestamp":1789152519344,"version":"build-2803163510"},"reference-count":31,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Public Health"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:p> Aim: To investigate the effects of adherence to the Mediterranean diet and familial dysmetabolisms on acne development. Methods: A community-based case\u2013control study was carried out in Italy enrolling cases as acneic outpatients of a dermatological ambulatory service and controls as clinically healthy acne-free subjects. Food consumption were evaluated with a validated food-frequency questionnaire, exploring the consumption of pasta, meat, cheese, fish, fruit, vegetables, and olive oil. Adherence to the traditional Mediterranean diet was assessed by a 10-point Mediterranean diet scale that incorporated the main characteristics of this diet. A logistic regression analysis estimated the variables who predicted the odds of being case, using those variables that at the univariate analysis yielded a p-value &lt;0.25. Results are presented as odds ratio (OR) or adjusted OR (AOR). Results: The study included 93 cases (36.6% males, median age 17 years) and 200 controls (32% males, median age 16 years). The Mediterranean diet score \u22656 revealed a protective effect towards acne (crude OR 0.22, 95% CI 0.08\u20130.64). Logistic regression analysis showed that familial hypercholesterolaemia, diabetes, and hypertension are strong risk factors for acne (AOR 8.79, 95% CI 1.67\u201346.22; 3.32, 95% CI 1.27\u20138.63; and 2.73, 95% CI 1.07\u20136.96, respectively), while the Mediterranean diet represents a protective factor (score \u22656, AOR 0.31, 95% CI 0.11\u20130.89). Conclusions: The odds for familial dysmetabolisms was higher in cases than in controls, confirming their role in determining or maintaining acne. Moreover, this is the first study demonstrating a protective role of the Mediterranean diet in the pathogenesis of acne. <\/jats:p>","DOI":"10.1177\/1403494812454235","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T04:26:30Z","timestamp":1343190390000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":42,"title":["Mediterranean diet and familial dysmetabolism as factors influencing the development of acne"],"prefix":"10.1177","volume":"40","author":[{"given":"Nevena","family":"Skroza","sequence":"first","affiliation":[{"name":"Dermatology Unit \u201cD. Innocenzi\u201d, Polo Pontino, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia","family":"Tolino","sequence":"additional","affiliation":[{"name":"Dermatology Unit \u201cD. 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