{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T02:10:46Z","timestamp":1788228646305,"version":"build-2803163510"},"reference-count":23,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100003887","name":"international myeloma foundation","doi-asserted-by":"publisher","award":["grant agreement No 173857"],"award-info":[{"award-number":["grant agreement No 173857"]}],"id":[{"id":"10.13039\/100003887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"european research council","doi-asserted-by":"publisher","award":["grant agreement No 716677"],"award-info":[{"award-number":["grant agreement No 716677"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Public Health"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>To evaluate the validity of recorded chronic disease diagnoses in Icelandic healthcare registries.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Eight different chronic diseases from multiple sub-specialties of medicine were validated with respect to accuracy, but not to timeliness. For each disease, 30 patients with a recorded diagnosis and 30 patients without the same diagnosis were randomly selected from &gt;80,000 participants in the iStopMM trial, which includes 54% of the Icelandic population born before 1976. Each case was validated by chart review by physicians using predefined criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall accuracy of the chronic disease diagnoses was 96% (95% CI 94\u201397%), ranging from 92 to 98% for individual diseases. After weighting for disease prevalence, the accuracy was estimated to be 98.5%. The overall positive predictive value (PPV) of chronic disease diagnosis was 93% (95% CI 89\u201396%) and the overall negative predictive value (NPV) was 99% (95% CI 96\u2013100%). There were disease-specific differences in validity, most notably multiple sclerosis, where the PPV was 83%. Other disorders had PPVs between 93 and 97%. The NPV of most disorders was 100%, except for hypertension and heart failure, where it was 97 and 93%, respectively. Those who had the registered chronic disease had objective findings of disease in 96% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>When determining the presence of chronic disease, diagnosis data from the Icelandic healthcare registries has a high PPV, NPV and accuracy. Furthermore, most diagnoses can be confirmed by objective findings such as imaging or blood testing. These findings can inform the interpretation of studies using diagnostic data from the Icelandic healthcare registries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14034948211059974","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T00:57:53Z","timestamp":1639443473000},"page":"173-178","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Validity of chronic disease diagnoses in Icelandic healthcare registries"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2162-8414","authenticated-orcid":false,"given":"S\u00e6mundur","family":"R\u00f6gnvaldsson","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorir Einarsson","family":"Long","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Iceland"},{"name":"Department of Nephrology, Lund University Hospital, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5017-3530","authenticated-orcid":false,"given":"Sigrun","family":"Thorsteinsdottir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Iceland"},{"name":"Department of Haematology, Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorvardur Jon","family":"Love","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Iceland"},{"name":"Department of Science and Research, Landspitali University Hospital, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigur\u00f0ur Yngvi","family":"Kristinsson","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Iceland, Iceland"},{"name":"Department of Haematology, Landsp\u00edtali University Hospital, Iceland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"bibr1-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2011.03.003."},{"key":"bibr2-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-017-0346-6"},{"key":"bibr3-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/gly205"},{"key":"bibr4-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13597"},{"key":"bibr5-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290450033020"},{"key":"bibr6-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1950.02910390001001"},{"key":"bibr7-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1056\/nejm196204192661602"},{"key":"bibr8-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000027350.85974.47"},{"key":"bibr9-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(90)90060-3"},{"key":"bibr10-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2009.02867.x"},{"key":"bibr11-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1177\/1403494819898573"},{"key":"bibr12-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"bibr13-14034948211059974","doi-asserted-by":"publisher","DOI":"10.2147\/clep.s91125"},{"key":"bibr14-14034948211059974","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.698751"},{"key":"bibr15-14034948211059974","volume-title":"International statistical classification of diseases and related health problems, 10th revision (ICD-10)","author":"WHO","year":"2016"},{"key":"bibr16-14034948211059974","unstructured":"Vistunarskr\u00e1 heilbrig\u00f0isstofnana [Hospital Discharge Register],www.landlaeknir.is\/tolfraedi-og-rannsoknir\/gagnasofn\/gagnasafn\/item12464\/Vistunarskra-heilbrigdisstofnana-(Hospital-Discharge-Register) (accessed 17 February 2021)."},{"key":"bibr17-14034948211059974","unstructured":"Samskiptaskr\u00e1 heilsug\u00e6slust\u00f6\u00f0va [Register of Primary Health Care Contacts],www.landlaeknir.is\/tolfraedi-og-rannsoknir\/gagnasofn\/gagnasafn\/item12460\/Samskiptaskra-heilsugaeslustodva-(Register-of-Primary-Health-Care-Contacts) (accessed 17 February 2021)."},{"key":"bibr18-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00480-w"},{"key":"bibr19-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2019.103208"},{"key":"bibr20-14034948211059974","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbi.2008.08.010"},{"key":"bibr21-14034948211059974","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2021"},{"key":"bibr22-14034948211059974","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"bibr23-14034948211059974","unstructured":"Harrell FE, Dupont C, et al. 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