{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:17:11Z","timestamp":1780575431191,"version":"3.54.1"},"reference-count":29,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>To investigate the prognosis of primary melanoma, we studied a Finnish population of 298 primary melanoma patients, the majority with stage I or II tumours. The median clinical follow-up (4.8 years) was acquired from the patients' records, and the overall survival thereafter was collected from patient registries. The median follow-up for overall survival was 9.5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The overall survival rate was 66.8 %. 24.5 % developed metastasis, 17.8 % died of melanoma, and 15.4 % died of some other cause. Surgical margins had no effect on survival. In univariate analysis the most significant prognostic factors for disease-free and overall survival were stage of tumour (p &lt; 0.0001), thickness of tumour (p &lt; 0.0001), depth of tumour invasion (p &lt; 0.0001) and tumour ulceration (p = 0.0005, p &lt; 0.0002). Ulceration was an unfavorable prognostic marker. Younger patients had better survival outcomes than older ones (p = 0.04). Accordingly, in the multivariate Cox model the independent prognostic factors for both disease-free and overall survival were stage of tumour and thickness of tumour. Tumour location on trunk was an independent adverse prognosticator for overall survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>We conclude that the prognosis of primary melanoma has improved in Finland in the last decades being in line with a global tendency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/145749690209100206","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T11:48:29Z","timestamp":1500378509000},"page":"166-171","source":"Crossref","is-referenced-by-count":11,"title":["Prognosis of Primary Melanoma"],"prefix":"10.1177","volume":"91","author":[{"given":"S.","family":"Ilmonen","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Asko-Seljavaara","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery, Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-L.","family":"Kariniemi","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Jeskanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pyrh\u00f6nen","sequence":"additional","affiliation":[{"name":"Department of Oncology and Radiotherapy, Turku University Central Hospital, Turku, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Muhonen","sequence":"additional","affiliation":[{"name":"University of Helsinki, Helsinki, Finland, at the moment working for Bristol-Myers-Squibb, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"issue":"6","key":"bibr1-145749690209100206","first-page":"725","volume":"23","author":"Garrison M","year":"1996","journal-title":"Semin Oncol"},{"key":"bibr2-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930601)71:11<3737::AID-CNCR2820711143>3.0.CO;2-7"},{"key":"bibr3-145749690209100206","first-page":"1947","volume-title":"Cancer principles and practice of oncology","author":"Balch CM","year":"1997"},{"key":"bibr4-145749690209100206","first-page":"927","volume":"1","author":"Handley WS","year":"1907","journal-title":"Lancet"},{"key":"bibr5-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197011000-00017"},{"key":"bibr6-145749690209100206","first-page":"691","volume":"145","author":"Breslow A","year":"1977","journal-title":"Surg Gynecol Obstet"},{"key":"bibr7-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199309000-00005"},{"key":"bibr8-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198805053181804"},{"key":"bibr9-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199609000-00002"},{"key":"bibr10-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08260-3"},{"key":"bibr11-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62768-2"},{"key":"bibr12-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1097\/00001622-199703000-00014"},{"key":"bibr13-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(05)70516-8"},{"key":"bibr14-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1992.01420040034005"},{"key":"bibr15-145749690209100206","volume-title":"Manual for Staging of Cancer","author":"AJCC. American Joint Committee on Cancer","year":"1992"},{"key":"bibr16-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000315)88:6<1484::AID-CNCR29>3.0.CO;2-D"},{"key":"bibr17-145749690209100206","first-page":"45","volume":"3","author":"Brandt G","year":"1956","journal-title":"Ann Chir Gyn"},{"key":"bibr18-145749690209100206","volume":"86","author":"Pakkanen M","year":"1977","journal-title":"Acta Universitatis Tamperensis ser A"},{"key":"bibr19-145749690209100206","unstructured":"Balch CM, Soong S-J, Shaw HM, Urist MM, McCarthy WH Cutaneous Melanoma. Eds Balch CM, Houghton AN, Milton GW, 2nd ed., 1992 pp. 165\u2013199."},{"key":"bibr20-145749690209100206","first-page":"705","volume":"29","author":"Clark WH","year":"1969","journal-title":"Cancer Res"},{"key":"bibr21-145749690209100206","doi-asserted-by":"crossref","unstructured":"Woods J, Soule E, Creagan E Metastasis and death in patients with thin melanomas (less than 0.76mm). Ann Surg 1983: 63\u201365.","DOI":"10.1097\/00000658-198307000-00012"},{"key":"bibr22-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G"},{"key":"bibr23-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2484::AID-CNCR2820751014>3.0.CO;2-U"},{"key":"bibr24-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/86.10.761"},{"key":"bibr25-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800621"},{"key":"bibr26-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199906000-00009"},{"key":"bibr27-145749690209100206","first-page":"1935","volume-title":"Cancer principles and practice of oncology","author":"Albino AP","year":"1997"},{"key":"bibr28-145749690209100206","doi-asserted-by":"publisher","DOI":"10.1080\/028418699431113"},{"issue":"6","key":"bibr29-145749690209100206","first-page":"1228","volume":"75","author":"Kraehn GM","year":"1995","journal-title":"A genetic disease? Cancer"}],"container-title":["Scandinavian Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/145749690209100206","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/145749690209100206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:49:06Z","timestamp":1777697346000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/145749690209100206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["10.1177\/145749690209100206"],"URL":"https:\/\/doi.org\/10.1177\/145749690209100206","relation":{},"ISSN":["1457-4969","1799-7267"],"issn-type":[{"value":"1457-4969","type":"print"},{"value":"1799-7267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}