{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:51:58Z","timestamp":1777938718459,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Advanced neoplastic diseases alter the immune response in cancer patients. The aim of this study was to evaluate the changes of T-lymphocyte subsets during postoperative adjuvant chemotherapy, and the relationship between T-lymphocyte subsets and tumor recurrence in AJCC stage III gastric cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Analysis of T-lymphocyte subsets was performed in 39 patients with stage III gastric adenocarcinoma who had undergone a curative gastric resection and postoperative chemotherapy. Circulating T-lymphocyte subsets were measured on venous blood by using flow cytometry and monoclonal antibodies on preoperative day 1, and postoperative months 1, 3, and 6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The 5-year disease-free survival rates of patients with stage 3a and 3b gastric cancer were 57.1 % and 33.3 %, respectively (p = 0.06). Values of CD3\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cells, and CD4\n                      <jats:sup>+<\/jats:sup>\n                      \/CD8\n                      <jats:sup>+<\/jats:sup>\n                      ratios were consistently lower in the recurrence group throughout the observation period. CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell counts were significantly lower in the recurrence group on preoperative day 1, and postoperative months 1 and 6. However, most values of the T-lymphocyte subsets showed no statistically significant difference when comparing the stage 3a and 3b disease patient groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      The results of this study suggest that immunosuppression associated with CD3\n                      <jats:sup>+<\/jats:sup>\n                      and CD4\n                      <jats:sup>+<\/jats:sup>\n                      T-cell depression is a risk factor for postoperative recurrence in patients with stage III gastric cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/145749690209100207","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T11:48:29Z","timestamp":1500378509000},"page":"172-177","source":"Crossref","is-referenced-by-count":6,"title":["T-Lymphocyte Subsets in Patients with AJCC Stage III Gastric Cancer during Postoperative Adjuvant Chemotherapy"],"prefix":"10.1177","volume":"91","author":[{"given":"M. Y.","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. G.","family":"Joh","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. R.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. I.","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.H.","family":"Koo","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Whang","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. O.","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine Korea University, Seoul, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2002,6,1]]},"reference":[{"key":"bibr1-145749690209100207","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)41788-3"},{"key":"bibr2-145749690209100207","first-page":"809","volume":"67","author":"Braun DP","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"bibr3-145749690209100207","first-page":"891","volume":"64","author":"Irving BA","year":"1991","journal-title":"The cytoplasmic domain of the T cell receptor x chain is sufficient to couple to receptor-associated signal transduction pathways"},{"key":"bibr4-145749690209100207","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.1995.10.3.164"},{"key":"bibr5-145749690209100207","doi-asserted-by":"publisher","DOI":"10.1159\/000226852"},{"key":"bibr6-145749690209100207","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930490310"},{"key":"bibr7-145749690209100207","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840401)53:7<1484::AID-CNCR2820530710>3.0.CO;2-T"},{"key":"bibr8-145749690209100207","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jjco.a039451"},{"key":"bibr9-145749690209100207","unstructured":"American Joint Committee on Cancer: AJCC cancer staging manual. 5th ed. 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