{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:54:56Z","timestamp":1777938896160,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Development of a pouch-related fistula tract is an uncommon but highly morbid complication to restorative proctocolectomy with ileal pouch-anal anastomosis. Pouch failure with permanent ileostomy is reported in 21%\u201330% of patients, yet the factors contributing to pouch excision remain poorly defined. The aim of this study was to determine the incidence and treatment results of complicated pouch-related fistula, as well as to evaluate factors involved in excision after pouch failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>The study was conducted as a retrospective study. All patients with diagnosed pouch-related fistulas were registered with information related to fistula classification, treatments, and outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and Conclusion:<\/jats:title>\n                    <jats:p>The final analysis included 48 (10.7%) of the 447 total ileal pouch-anal anastomosis patients with complicated pouch-related fistulas. Pouch-vaginal fistulas, pouch-perianal fistulas, and other pouch-related fistulas were observed in 19 (63%), 29 (60%), and 10 (21%) patients, respectively, corresponding to an accumulated risk of 8%, 6%, and 2%, respectively. Time from ileal pouch-anal anastomosis surgery to fistula presentation was 24 (0.2\u2013212) months. Overall pouch failure, defined as pouch excision or a diverting stoma, was seen in 34 (71%) patients, while pouch excision was seen in 23 (48%) of the patients. Patients who developed Crohn\u2019s disease had a significantly higher risk of pouch excision, as did patients with an early onset of the fistula after ileal pouch-anal anastomosis ( P\u2009=\u20090.006 and P\u2009=\u20090.007, respectively). In conclusion, the present study demonstrated a high risk of pouch failure in patients with complicated pouch-related fistulas. Furthermore, it showed that Crohn\u2019s disease and the development of early onset fistulas are associated with pouch excision.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1457496915613648","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T22:50:07Z","timestamp":1445986207000},"page":"163-167","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Poor Outcomes of Complicated Pouch-Related Fistulas after Ileal Pouch-Anal Anastomosis Surgery"],"prefix":"10.1177","volume":"105","author":[{"given":"M. D.","family":"Kjaer","sequence":"first","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Medical Gastroenterology, Odense University Hospital, Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Qvist","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, Odense C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"bibr1-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5464"},{"key":"bibr2-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1402-6"},{"key":"bibr3-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236254"},{"key":"bibr4-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000090940.39838.6a"},{"key":"bibr5-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5071"},{"key":"bibr6-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00689.x"},{"key":"bibr7-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800849"},{"key":"bibr8-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/BF02055375"},{"key":"bibr9-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4278"},{"key":"bibr10-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900394"},{"key":"bibr11-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318206ea42"},{"key":"bibr12-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000094"},{"key":"bibr13-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554497"},{"key":"bibr14-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800800750"},{"key":"bibr15-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1993.01420160075012"},{"key":"bibr16-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1197-x"},{"key":"bibr17-1457496915613648","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2005.00800.x"}],"container-title":["Scandinavian Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1457496915613648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1457496915613648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1457496915613648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:55:25Z","timestamp":1777697725000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1457496915613648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1177\/1457496915613648"],"URL":"https:\/\/doi.org\/10.1177\/1457496915613648","relation":{},"ISSN":["1457-4969","1799-7267"],"issn-type":[{"value":"1457-4969","type":"print"},{"value":"1799-7267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}