{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T02:57:47Z","timestamp":1789441067161,"version":"build-2803163510"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T00:00:00Z","timestamp":1547164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100008376","name":"Helsinki University Central Hospital","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008376","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Finnish Pediatric Research Foundation"},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The incidence of pancreaticobiliary maljunction is thought to approximate 1:100,000 within Western populations. We aimed to study the significance of pancreaticobiliary maljunction in biliary tract malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Medical records and magnetic resonance cholangiopancreatography images of 252 consecutive patients treated for biliary malignancies during 2005\u20132016 were reviewed. Patients with other known risk factors for biliary cancers (n\u2009=\u200927) were excluded. A common pancreaticobiliary channel measuring \u2a7e10\u2009mm outside the duodenal wall was defined as pancreaticobiliary maljunction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main Results:<\/jats:title>\n                    <jats:p>Of the 225 patients, a reliably interpretable preoperative magnetic resonance cholangiopancreatography was available for 73 (32%). Sex (47% vs 57% females) and age at diagnosis (67 vs 66\u2009years) were similar among patients with or without an magnetic resonance cholangiopancreatography (p\u2009=\u2009ns for both). In magnetic resonance cholangiopancreatography, a pancreaticobiliary maljunction with a median length of 20\u2009mm (range 10\u201323\u2009mm) was identified in four patients (5.5%, 95% confidence interval 1.6\u201314), while none had evident accompanying biliary tree dilatation. Pancreaticobiliary maljunction patients were significantly more often females (100% vs 43%, p\u2009=\u20090.043), less likely to have intrahepatic bile duct cancer (0% vs 65%, p\u2009=\u20090.019) while more likely to have gallbladder cancer (75% vs 22%, p\u2009=\u20090.044) compared to the others. Age at diagnosis (66 vs 67\u2009years, p\u2009=\u20090.898), extrahepatic bile duct cancer incidence (25% vs 13%, p\u2009=\u20090.453), and survival status at last follow-up (50% vs 42% alive, p\u2009=\u20091.000) were comparable between the subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The prevalence of pancreaticobiliary maljunction is substantially higher in adults with biliary malignancies than one would expect based on its incidence, reinforcing the etiologic role of pancreaticobiliary maljunction especially in females with gallbladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1457496918822617","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T04:48:06Z","timestamp":1547182086000},"page":"285-290","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Increased prevalence of pancreaticobiliary maljunction in biliary malignancies"],"prefix":"10.1177","volume":"108","author":[{"given":"I.","family":"Hyv\u00e4rinen","sequence":"first","affiliation":[{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children\u2019s Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hukkinen","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children\u2019s Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kivisaari","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Parviainen","sequence":"additional","affiliation":[{"name":"HUS Medical Imaging Center, Radiology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nordin","sequence":"additional","affiliation":[{"name":"Liver and Transplantation Surgery, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. P.","family":"Pakarinen","sequence":"additional","affiliation":[{"name":"Section of Pediatric Surgery, Pediatric Liver and Gut Research Group, Children\u2019s Hospital, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"bibr1-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411807"},{"key":"bibr2-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.10.038"},{"key":"bibr3-1457496918822617","unstructured":"Cancer Society of Finland. Internet: Suomen Sy\u00f6p\u00e4rekisteri, www.syoparekisteri.fi (2016, accessed 21 07 2017)."},{"key":"bibr4-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24351"},{"key":"bibr5-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1159\/000324688"},{"key":"bibr6-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-007-1276-8"},{"key":"bibr7-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1016\/S1499-3872(11)60098-2"},{"key":"bibr8-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1268-z"},{"key":"bibr9-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.08.024"},{"key":"bibr10-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-012-0611-2"},{"key":"bibr11-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0336-0"},{"key":"bibr12-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1159\/000286502"},{"key":"bibr13-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00534-013-0606-2"},{"issue":"5","key":"bibr14-1457496918822617","first-page":"434","volume":"52","author":"Singham J","year":"2009","journal-title":"Can J Surg"},{"key":"bibr15-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2010.195974"},{"key":"bibr16-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(98)70247-0"},{"key":"bibr17-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.07.003"},{"key":"bibr18-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00276-016-1669-y"},{"key":"bibr19-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-014-1015-2"},{"key":"bibr20-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1159\/000055902"},{"key":"bibr21-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.141.11.1066"},{"key":"bibr22-1457496918822617","first-page":"1649","volume":"52","author":"Kusano T","year":"2005","journal-title":"Hepatogastroenterology"},{"key":"bibr23-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1007\/s005340200035"},{"key":"bibr24-1457496918822617","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hye020"},{"key":"bibr25-1457496918822617","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.946084"}],"container-title":["Scandinavian Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1457496918822617","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1457496918822617","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1457496918822617","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:57:06Z","timestamp":1777697826000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1457496918822617"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,11]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1177\/1457496918822617"],"URL":"https:\/\/doi.org\/10.1177\/1457496918822617","relation":{},"ISSN":["1457-4969","1799-7267"],"issn-type":[{"value":"1457-4969","type":"print"},{"value":"1799-7267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,11]]}}}