{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T05:06:41Z","timestamp":1780722401816,"version":"3.54.1"},"reference-count":26,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T00:00:00Z","timestamp":1550707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background &amp; Aims:<\/jats:title>\n                    <jats:p>The prevalence of gallstone disease increases with age, being early cholecystectomy the most accepted treatment in the vast majority of patients in order to prevent complications and recurrence. The aim of this study is to determine the recurrence rate and its possible predictors after initial non-operative management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>We reviewed a consecutive series of patients, older than 65\u2009years, admitted for a gallstone-related disease and treated with a non-operative management between January 2010 and December 2013. We analyzed comorbidities, clinical data, diagnosis, management, recurrence, and its treatment. Median follow-up after the discharge was 2\u2009years. Recurrence was analyzed by a Kaplan\u2013Meier survival curve. Possible recurrence\u2019s predictors were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The study included 226 patients. Mean age was 80.4 \u00b1 7.2\u2009years, 127 (56%) were female. The main causes of index hospitalization were acute cholecystitis (58%) and biliary pancreatitis (18.1%). After 2\u2009years of follow-up, the recurrence rate was 39.8%; mean time to recurrence was 255.2 \u00b1 42.1\u2009days, 81% of patients recurred within 1\u2009year. Bile duct disease implied a higher recurrence rate than the gallbladder disease group (52% vs 33%, p &lt; 0.001). Subjects with two or more diagnoses during index admission presented higher recurrence rate (32% vs 49%, p &lt; 0.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>More than a third of elderly patients could present a recurrence within 2\u2009years after initial non-operative management. Early cholecystectomy should be considered at index admission in order to prevent recurrence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1457496919832147","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T05:58:44Z","timestamp":1550815124000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":26,"title":["Conservative Management of Gallstone Disease in the Elderly Population: Outcomes and Recurrence"],"prefix":"10.1177","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0645-9050","authenticated-orcid":false,"given":"I","family":"Mora-Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Di Martino","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AC","family":"Bonito","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"VV","family":"Jodra","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario Ram\u00f3n y Cajal, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SG","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Hospital General Universitario Gregorio Mara\u00f1\u00f3n, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Martin-Perez","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery, Hospital Universitario de la Princesa, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,2,21]]},"reference":[{"key":"bibr1-1457496919832147","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8627(03)00072-5"},{"key":"bibr2-1457496919832147","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2014.12.012"},{"issue":"41","key":"bibr3-1457496919832147","first-page":"1275","volume":"48","author":"Bedirli 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