{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:56:26Z","timestamp":1777938986024,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>Per oral endoscopic myotomy (POEM) has become an established treatment for achalasia, but no Scandinavian studies with long-term follow-up exist. This study from a tertiary referral center in Norway investigates the short-, mid-, and long-term feasibility, safety, efficacy, and complications of POEM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Prospective data from the first 84 patients who underwent POEM from 2014 to 2019 were analyzed. The median follow-up time was 44 months. Clinical success was defined as the Eckardt score (ES) \u2a7d3, and reflux as pathological if the acid exposure time (pH &lt; 4) was more than 6%. ES was used for symptom evaluation before, and at 6, 12, and up to 64 months after POEM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>A total of 50 males and 34 females were included. A total of 43 (51%) were treatment na\u00efve, 24 (28.6%) had been previously treated with botulinum toxin, pneumatic balloon dilatation, or both, and 17 (20.2%) were previously treated with Heller\u2019s myotomy. The median post-POEM ES at 12 months was 1 (0\u20139), compared to pre-POEM 7 (4\u201312) (p &lt; 0.01). At 12 months after POEM, clinical success persisted in 74 patients (88.1%). Clinical success was the highest for patients who were na\u00efve to treatment, 41\/43 (95%), and lower for those previously treated with Heller\u2019s myotomy 12\/17 (70.6%). Long-term follow-up at 5\u20136 years of 42 patients showed a clinical success rate of 94%. We experienced adverse events in five patients (6%). Post-POEM pathological reflux was found in 46% (28\/61). After 3\u20134 years, the median ES was 1, and after 5\u20136 years, it was 2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>POEM was safe and relieved the symptoms of achalasia significantly and persistently. The procedure had a better outcome in treatment na\u00efve than previously treated patients. However, POEM is associated with significantly increased esophageal acid exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Twitter summary<\/jats:title>\n                    <jats:p>Norwegian single-center study: POEM had a clinical success rate of 94% after 5\u20136 years since its introduction at the center in 2014, providing a safe and effective treatment for achalasia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969221139706","type":"journal-article","created":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T05:25:58Z","timestamp":1670563558000},"page":"3-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["The outcome of primary per oral endoscopic myotomy (POEM) for treatment of achalasia: Norwegian single-center experience with long-term follow-up"],"prefix":"10.1177","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6476-1680","authenticated-orcid":false,"given":"Khanh Do-Cong","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Medicine Haukeland University Hospital Jonas Lies vei 65 5021 Bergen"},{"name":"Norway Department of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Bergen Research Group for Advanced Gastrointestinal Endoscopy (BRAGE) Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9575-6051","authenticated-orcid":false,"given":"Sigurd Strumse","family":"Lauritzen","sequence":"additional","affiliation":[{"name":"Bergen Research Group for Advanced Gastrointestinal Endoscopy (BRAGE), Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erling","family":"Tjora","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Odd Helge","family":"Gilja","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"National Centre for Ultrasound in Gastroenterology, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Gunnar","family":"Hatlebakk","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"A\u00dfmus","sequence":"additional","affiliation":[{"name":"Centre for Clinical Research, Haukeland University Hospital, Bergen, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roald Flesland","family":"Havre","sequence":"additional","affiliation":[{"name":"Department of Medicine, Haukeland University Hospital, Bergen, Norway"},{"name":"Department of Clinical Medicine, University of Bergen, Bergen, Norway"},{"name":"Bergen Research Group for Advanced Gastrointestinal Endoscopy (BRAGE), Haukeland University Hospital, Bergen, 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