{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:16:45Z","timestamp":1791314205395,"version":"4.3.1"},"reference-count":28,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T00:00:00Z","timestamp":1708992000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010794","name":"Medicinska fakulteten, Umea Universitet","doi-asserted-by":"publisher","award":["Centrala ALF"],"award-info":[{"award-number":["Centrala ALF"]}],"id":[{"id":"10.13039\/501100010794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014689","name":"Region Vasternorrland","doi-asserted-by":"publisher","award":["Visare Norr 931408 and 968146"],"award-info":[{"award-number":["Visare Norr 931408 and 968146"]}],"id":[{"id":"10.13039\/501100014689","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>International guidelines recommend open surgery for atypical ductal hyperplasia (ADH) in the breast due to risk of underestimating malignant disease. Considering the ongoing randomized trials of active surveillance of low-risk ductal carcinoma in situ (DCIS), it seems reasonable to define a low-risk group of women with ADH where a conservative approach is appropriate. The aim here was to evaluate the management and risk for upgrade of lesions diagnosed as ADH in percutaneous breast biopsies in two Swedish hospitals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>All women with a screen-detected or symptomatic breast lesion breast imaging-reporting and data system (BI-RADS) 2\u20134 and a percutaneous biopsy showing ADH between 2013 and 2022 at Sundsvall Hospital and Ume\u00e5 University Hospital were included. Information regarding imaging, histopathology, clinical features, and management was retrieved from medical records. Odds ratio (OR) and 95% confidence intervals (CI) for upgrade to malignant diagnosis after surgery were calculated by logistic regression analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Altogether, 101 women were included with a mean age 56.1 (range 36\u201393)\u2009years. Most women were selected from the national mammography screening program due to microcalcifications. Biopsies were performed with vacuum-assisted biopsy (60.4%) or core-needle biopsy (39.6%). Forty-eight women (47.5%) underwent surgery, of which 11 were upgraded to DCIS, and 7 to invasive breast cancer (upgrade rate 37.5%). Among the 53 women managed conservatively (median follow-up 74\u2009months), one woman (1.9%) developed subsequent ipsilateral DCIS. The combined upgrade rate was 18.8%. No clinical variable statistically significantly correlating to risk of upgrade was identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The upgrade rate of 37.5% in women undergoing surgery compared to an estimated 5-year risk of ipsilateral malignancy at 1.9% in women managed conservatively indicate that non-surgical management of select women with ADH is feasible. Research should focus on defining reproducible criteria differentiating high-risk from low-risk ADH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969241234115","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:17:01Z","timestamp":1709079421000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Management and risk of upgrade of atypical ductal hyperplasia in the breast: A population-based retrospective cohort study"],"prefix":"10.1177","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0571-7265","authenticated-orcid":false,"given":"Charlotta","family":"Wadsten","sequence":"first","affiliation":[{"name":"Department of Surgery Sundsvall Hospital S-856 43 Sundsvall Sweden"},{"name":"Department of Diagnostics and Intervention\/Surgery Ume\u00e5 University Ume\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunilla","family":"Rask","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences\/Pathology, Ume\u00e5 University, Ume\u00e5, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"bibr1-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19930215)71:4<1258::AID-CNCR2820710415>3.0.CO;2-I"},{"key":"bibr2-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A"},{"key":"bibr3-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900201)65:3<518::AID-CNCR2820650324>3.0.CO;2-O"},{"key":"bibr4-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-016-3935-4"},{"key":"bibr5-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-017-4253-1"},{"key":"bibr6-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2017.11.005"},{"key":"bibr7-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-05071-1"},{"key":"bibr8-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2019190748"},{"key":"bibr9-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.0217"},{"key":"bibr10-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2011.06.014"},{"key":"bibr11-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2010.06.004"},{"key":"bibr12-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2989-3"},{"key":"bibr13-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-016-5512-9"},{"key":"bibr14-14574969241234115","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11061120"},{"key":"bibr15-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-010-1127-8"},{"key":"bibr16-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05890-1"},{"key":"bibr17-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1407164"},{"key":"bibr18-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000004849"},{"key":"bibr19-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-007-9824-0"},{"key":"bibr20-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.08.011"},{"key":"bibr21-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.12885"},{"key":"bibr22-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2018.04.004"},{"key":"bibr23-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2575-0"},{"key":"bibr24-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2023.05.008"},{"key":"bibr25-14574969241234115","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.114"},{"key":"bibr26-14574969241234115","unstructured":"Magny SJ, Shikhman R, Keppke AL: Breast Imaging Reporting and Data System. 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