{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T16:03:52Z","timestamp":1782662632411,"version":"3.54.5"},"reference-count":24,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T00:00:00Z","timestamp":1728777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objective:<\/jats:title>\n                    <jats:p>The incidence of early-onset colorectal cancer among the young (&lt;50\u2009years) has been reported to have risen in last decades. This retrospective study aimed to investigate the characteristics of early-onset rectal cancers (EO-RCs) and potential changes in proportion of EO-RCs, and further to report the mortality and recurrence rates of EO-RCs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In the years 2007\u20132021, 2557 rectal cancer (RC) patients were operated in Helsinki University Hospital and of them 147 were 18\u201349\u2009years old. Cumulative overall survival (OS), disease-specific survival, and disease-free survival were calculated using the Kaplan\u2013Meier analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The percentual amount of the EO-RCs varied between 2.5% and 11.3% annually and there was no perceivable trend. Majority were adenocarcinomas (98.7%), of which 8.8% were mucinous. Predisposing factors such as Lynch syndrome, polyposis, or ulcerative colitis were seen in 26 patients (17.7%) and in 10 of 22 patients (45.5%) under 35\u2009years. The cumulative 5-year OS was 91.9% in stage I, 93.3% in stage II, 86.7% in stage III, and 50.0% in stage IV disease. Metastatic recurrence was found in 22 cases (18.4%) and local recurrence in 8 patients (5.4%) and 6 patients had both.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our cohort of 147 EO-RC patients, OS was good and the clinical course did not seem to differ much from the course of RC in general population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969241282543","type":"journal-article","created":{"date-parts":[[2024,10,13]],"date-time":"2024-10-13T04:42:19Z","timestamp":1728794539000},"page":"22-34","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Early-onset rectal cancer: Experience of a single-center, high-volume unit"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-0870","authenticated-orcid":false,"given":"Taru M.","family":"Lehtonen","sequence":"first","affiliation":[{"name":"Department of Surgery HUS Helsinki University Hospital and University of Helsinki, Jorvi Hospital,Espoo 20540, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura E.","family":"Koskenvuo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Helsinki University Hospital and University of Helsinki, Jorvi, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna H.","family":"Lepist\u00f6","sequence":"additional","affiliation":[{"name":"Department of Surgery, Helsinki University Hospital and University of Helsinki, Jorvi, Finland"},{"name":"Applied Tumor Genomics, Research Programs Unit, University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djw322"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2200869"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317592"},{"key":"e_1_3_2_5_2","unstructured":"Pitk\u00e4niemi J Malila N Virtanen A et al: Cancer in Finland 2018 (Publication No. 94 2020). Cancer Society of Finland https:\/\/syoparekisteri.fi\/assets\/files\/2020\/05\/Cancer_in_Finland_2018-report.pdf"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09460-0"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.12.068"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00426-X"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2016.5194"},{"issue":"7","key":"e_1_3_2_10_2","first-page":"2727","article-title":"Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies","volume":"29","author":"Triantafillidis JK","year":"2009","unstructured":"Triantafillidis JK, Nasioulas G, Kosmidis PA: Colorectal cancer and inflammatory bowel disease: Epidemiology, risk factors, mechanisms of carcinogenesis and prevention strategies. Anticancer Res 2009;29(7):2727\u20132737.","journal-title":"Anticancer Res"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000639"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00588-X"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12417"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2012.61"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001884"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1714533"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-019-03312-3"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.4503"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15112979"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01230.x"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.7784"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3878"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)70168-5"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21772"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0738-1"}],"container-title":["Scandinavian Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14574969241282543","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/14574969241282543","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/14574969241282543","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:59:46Z","timestamp":1777697986000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/14574969241282543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,13]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1177\/14574969241282543"],"URL":"https:\/\/doi.org\/10.1177\/14574969241282543","relation":{},"ISSN":["1457-4969","1799-7267"],"issn-type":[{"value":"1457-4969","type":"print"},{"value":"1799-7267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,13]]}}}