{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:56:45Z","timestamp":1777939005081,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Helsinki University Hospital Research Fund","award":["2020224"],"award-info":[{"award-number":["2020224"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background and aims:<\/jats:title>\n                    <jats:p>Neoadjuvant short-course radiotherapy (SCRT) prior to surgery has been used to reduce local recurrences in moderately advanced rectal cancer (RC). Total mesorectal excision (TME) surgery by itself can reduce the local recurrence rate in these patients. The objective was to assess whether discontinuing neoadjuvant SCRT had a negative impact on survival and local recurrence rates of moderately advanced RC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective study examined 137 consecutive patients (67 neoadjuvant SCRT, 70 TME without neoadjuvant therapy) treated for rT1-3N1M0 RC without extramural venous invasion (EMVI) or a threatened surgical margin between January 2016 and March 2020 in a tertiary rectal surgery referral center. The primary objective was the impact of neoadjuvant therapy on overall, cancer-specific, and disease-free survival, and local recurrence rate. Secondary outcomes were risk factors affecting survival. The analyses were conducted on the total study cohort as well as a propensity score matched cohort of the same patient group, with the matching predicated upon age, gender, and histological T score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The oncological outcomes were similar between the two different treatment groups. The 5-year cumulative overall survival rate, calculated using the Kaplan\u2013Meier method, was 89.6% in the neoadjuvant SCRT group and 83.5% in the surgery-only group (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.570), with the corresponding cancer-specific survival rates at 97.0% and 98.4% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.219) and disease-free survival rates at 97.0% and 91.9% (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.438). No local recurrencies were detected in either group during the 5-year follow-up period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The omission of neoadjuvant SCRT in rT1-3N1M0 RC with no EMVI and no threatened resection margin caused no adverse effects on the survival of the patients. Based on this series, it appears that avoiding SCRT does not compromise the oncological outcome in these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969251319201","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T02:11:56Z","timestamp":1739499116000},"page":"202-209","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of oncological outcomes of T1-3 N1 rectal cancer patients treated with neoadjuvant radiotherapy versus no radiotherapy: A retrospective cohort study"],"prefix":"10.1177","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-6634","authenticated-orcid":false,"given":"Suvi","family":"Marjasuo","sequence":"first","affiliation":[{"name":"Department of Radiology, Helsinki University Hospital, Helsinki Finland University of Helsinki Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Koskenvuo","sequence":"additional","affiliation":[{"name":"Gastroenterological Surgery, Helsinki University Hospital, Helsinki, Finland"},{"name":"University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Lepist\u00f6","sequence":"additional","affiliation":[{"name":"Department of Surgery, Helsinki University Hospital, Helsinki, Finland"},{"name":"University of Helsinki, Helsinki, Finland"},{"name":"Applied Tumor Genomics, Research Projects Unit Organization, University of Helsinki, Helsinki, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1998.00735.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(99)00080-X"},{"issue":"8","key":"e_1_3_2_4_2","first-page":"643","article-title":"Rectal cancer: The influence of type of operation on local recurrence and survival","volume":"162","author":"Bjerkeset T","year":"1996","unstructured":"Bjerkeset T, Edna TH: Rectal cancer: The influence of type of operation on local recurrence and survival. Eur J Surg 1996;162(8):643\u2013648.","journal-title":"Eur J Surg"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701697720"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx224"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-015-4067-3"},{"key":"e_1_3_2_8_2","first-page":"1","article-title":"The multimodal management of locally advanced rectal cancer: Making sense of the new data","volume":"42","author":"Zwart WH","year":"2022","unstructured":"Zwart WH, Hotca A, Hospers GAP, et al: The multimodal management of locally advanced rectal cancer: Making sense of the new data. 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