{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:19:10Z","timestamp":1785507550480,"version":"3.56.0"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Scand J Surg"],"abstract":"<jats:sec>\n                    <jats:title>Background and Aims:<\/jats:title>\n                    <jats:p>Endoscopic resection (ER) for early gastric cancer is a well-established treatment. Previous research is predominantly based on Asian patients. The aim of this study was to evaluate treatment strategies and outcomes for early gastric cancer in Sweden, based on data from a population-based cancer registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We conducted a nationwide population-based cohort study using data from the Swedish National Registry for Esophageal and Gastric Cancer. All patients with pT1N0M0 gastric cancer or high-grade dysplasia who underwent surgical or ER between 2006 and 2022 were included. The primary endpoint was 5-year overall survival. Secondary endpoints included length of hospital stay, 30- and 90-day mortality rates, and postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      In total, 278 patients were included. Of these, 189 (68.0%) underwent surgery and 89 (32.0%) ER. The two groups were comparable regarding baseline parameters (age, sex, smoking, ASA-score) but the surgery group had a higher clinical T-stage. The 5-year overall survival was 67 of 104 patients (64.4%) in the surgery group and 24 of 37 patients (64.9%) in the ER group. Multivariable Cox regression showed no difference between the groups (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.685). ER was associated with a shorter hospital stay (median 1\u2009day compared to 9\u2009days for surgery,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The 30- and 90-day mortality was 0 and 1 (1.1%) for ER and 4 (2.1%) and 9 (4.8%) for surgery (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.310 and 0.176, respectively). Complications occurred in 9 patients (12.7%) in the ER group and 42 (25.6%) in the surgery group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In this population-based study, ER and surgery had comparable 5-year overall survival for early gastric cancer. ER was associated with a shorter hospital stay and fewer postoperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/14574969261440339","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:11:03Z","timestamp":1785345063000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of early gastric cancer in Sweden: A nationwide registry-based cohort study"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8139-9728","authenticated-orcid":false,"given":"Henrik","family":"Maltzman","sequence":"first","affiliation":[{"name":"Department of Upper Abdominal Diseases Karolinska University Hospital H\u00e4lsov\u00e4gen 13 141 57 Huddinge Sweden, Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Elbe","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jeremiasen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Sk\u00e5ne University Hospital Lund, Lund, Sweden"},{"name":"Faculty of Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Omae","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Baldaque-Silva","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"},{"name":"Advanced Endoscopy Center Carlos Moreira da Silva, Department of Gastroenterology, Pedro Hispano Hospital, Matosinhos, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"von Seth","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Lindblad","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"Klevebro","sequence":"additional","affiliation":[{"name":"Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden"},{"name":"Division of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-023-00747-0"},{"issue":"3","key":"e_1_3_3_3_2","article-title":"Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007-2016 from a national quality register","volume":"33","author":"Jeremiasen M","year":"2020","unstructured":"Jeremiasen M, Linder G, Hedberg J, et al: Improvements in esophageal and gastric cancer care in Sweden-population-based results 2007-2016 from a national quality register. 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Endosc Int Open 2021;9(7):E989\u201393.","journal-title":"Endosc Int Open"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-06609-6"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-020-07677-3"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-018-06624-7"},{"issue":"5","key":"e_1_3_3_25_2","first-page":"277","article-title":"Risk factors for complications of total\/Subtotal gastrectomy for gastric cancer: prospectively collected, based on the clavien-dindo classification system","volume":"20","author":"Nevo Y","year":"2018","unstructured":"Nevo Y, Goldes Y, Barda L, et al: Risk factors for complications of total\/Subtotal gastrectomy for gastric cancer: prospectively collected, based on the clavien-dindo classification system. 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